Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Phytochemical study and biological evaluation of chemical constituents of Platanus orientalis and Platanus × acerifolia buds
Δημιουργός/Συγγραφέας:	Thai Q.D. Tchoumtchoua J. Makropoulou M. Boulaka A. Meligova A.K. [EL] Μήτσιου, Δήμητρα[EN] Mitsiou, Dimitra J. Mitakou S. Michel S. Halabalaki M. [EL] Αλέξης, Μιχαήλ Ν.[EN] Alexis, Michael N. Skaltsounis L.A.
Εκδότης:	Elsevier Ltd
Ημερομηνία:	2016
Γλώσσα:	Αγγλικά
ISSN:	0031-9422
DOI:	10.1016/j.phytochem.2016.04.006
Άλλο:	PubMed ID: 27179684
Περίληψη:	One flavonol glycoside, two O-isoprenylated flavonols, one α,α-dimethylallyl flavonol, one dihydrochalcone, two furanocoumarins and one terpenoid previously undescribed, along with 42 known compounds were isolated from the buds of two European Platanaceae, Platanus orientalis and Platanus × acerifolia. Their chemical structures were elucidated on the basis of spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (COSY, NOESY, HSQC, and HMBC) experiments, as well as HRMS data. The estrogen-like and antiestrogen-like activity of dichloromethane and methanol extracts of P. orientalis and P. × acerifolia buds and isolated compounds was evaluated using estrogen-responsive cell lines. The potency of selected estrogen agonists to regulate gene expression through ERα and/or ERβ was compared with their in vitro osteoblastogenic activity. Kaempferol and 8-C-(1,1-dimethyl-2-propen-1-yl)-5,7-dihydroxyflavonol displayed osteoblastogenic as well as ERα-mediated estrogenic activity similar to estradiol.
Τίτλος πηγής δημοσίευσης:	Phytochemistry
Τόμος/Κεφάλαιο:	130
Σελίδες:	170-181
Θεματική Κατηγορία:	[EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Coumarins Dihydrochalcones Estrogenic activity Flavonoids Osteoblast differentiation Phytoestrogens Platanaceae Platanus orientalis Platanus × acerifolia
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2016 Elsevier Ltd
Σημειώσεις:	OSTEOPRO-1076; European Regional Development Fund, FEDER. The present work was funded by the European Regional Development Fund and National Resources - SYNERGASIA 2009 (GAN: OSTEOPRO-1076). Quoc Dang Thai and Job Tchoumtchoua acknowledge the Hellenic State Scholarships Foundation (IKY) for their PhD Scholarships.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο