Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Impact of β-glucan on the Fecal Water Genotoxicity of Polypectomized Patients
Δημιουργός/Συγγραφέας:	Turunen K.T. [EL] Πλέτσα, Βασιλική[EN] Pletsa, Vassiliki [EL] Γεωργιάδης, Παναγιώτης[EN] Georgiadis, Panagiotis Triantafillidis J.K. Karamanolis D. Kyriacou A.
Εκδότης:	Routledge
Ημερομηνία:	2016
Γλώσσα:	Αγγλικά
ISSN:	0163-5581
DOI:	10.1080/01635581.2016.1156713
Άλλο:	PubMed ID: 27043932
Περίληψη:	The aim of the study was to determine the effect of β-glucan on the cytotoxicity and genotoxicity of polypectomized patient's fecal water (FW). Polypectomized volunteers (n = 69) were randomly assigned to consume bread with or without β-glucan, for 3 months. FW was collected at the beginning (t = 0), the 30th and 90th day and 2 wk after the intervention. Cytotoxicity and genotoxicity were estimated on Caco-2 cells, using trypan blue exclusion test and comet assay, respectively. Gastrointestinal symptoms were recorded and subjects kept a 3-day food diary at baseline and after completion. Trypan blue exclusion test revealed cell survival of approximately 87% after incubation with FW. The FW samples showed 49% genotoxicity at the baseline. Genotoxicity in the intervention group decreased during the trial reaching statistical significance on the 90th day compared to control. An increase was noticed 2 wk after the trial, but it still remained significantly lower compared to control. Group-specific analysis for β-glucan also revealed significant decrease in the genotoxicity on the 90th day compared to baseline. β-glucan ingestion in polypectomized patients significantly decreased the genotoxicity of their FW. Our findings suggest that β-glucan consumption could possibly provide protection against colon cancer development.
Τίτλος πηγής δημοσίευσης:	Nutrition and Cancer
Τόμος/Κεφάλαιο:	68
Τεύχος:	4
Σελίδες:	560-567
Θεματική Κατηγορία:	[EL] Τοξικολογία[EN] Toxicology. Poisons
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2016 Taylor & Francis Group, LLC.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο