Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Vitamin E derivatives: A patent review (2010 - 2015)
Δημιουργός/Συγγραφέας:	[EL] Κουφάκη, Μαρία[EN] Koufaki, Maria
Εκδότης:	Taylor and Francis Ltd
Ημερομηνία:	2016
Γλώσσα:	Αγγλικά
ISSN:	1354-3776
DOI:	10.1517/13543776.2016.1106476
Άλλο:	PubMed ID: 26514333
Περίληψη:	Introduction: The vitamin E family consists of four tocopherols and four tocotrienols. -Tocopherol is the most studied member of this family for its antioxidant and non-antioxidant properties, while tocotrienols have attracted recent research interest. The structural motifs of the vitamin E family and specifically the chroman moiety, are amenable to various modifications in order to improve their bioactivities towards numerous therapeutic targets.Areas covered: This review includes the patent literature from 2010 - 2015 related to vitamin E derivatives and it is focused on 2-, 5- or 6-substituted chroman analogues. The patent search was performed using Reaxys® and esp@cenet.Expert opinion: The chroman moiety of vitamin E is a privileged structure and an essential pharmacophore which inspired organic chemists to synthesize new analogues with improved bioactivities. Modifications at the 2- and 5- positions of the chroman ring resulted in very interesting active compounds in cellular and animal models of diseases related to oxidative stress. More recent publications and patents reported 6-substituted chromans as anticancer agents in vitro and in vivo. Additionally, an emerging interest is observed towards the use of vitamin E analogues incorporated in drug delivery systems and for medical imaging as contrast agents or fluorescent probes.
Τίτλος πηγής δημοσίευσης:	Expert Opinion on Therapeutic Patents
Τόμος/Κεφάλαιο:	26
Τεύχος:	1
Σελίδες:	35-47
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	Anticancer Antioxidant Chroman Drug delivery Vitamin E
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2015 Taylor & Francis.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο