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Εξειδίκευση τύπου : Άρθρο σε επιστημονικό περιοδικό
Τίτλος: Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
Δημιουργός/Συγγραφέας: Kato N.
Loh M.
Takeuchi F.
Verweij N.
Wang X.
Zhang W.
NKelly T.
Saleheen D.
Lehne B.
Leach I.M.
Drong A.W.
Abbott J.
Wahl S.
Tan S.-T.
Scott W.R.
Campanella G.
Chadeau-Hyam M.
Afzal U.
Ahluwalia T.S.
Bonder M.J.
Chen P.
Dehghan A.
Edwards T.L.
Esko T.
Go M.J.
Harris S.E.
Hartiala J.
Kasela S.
Kasturiratne A.
Khor C.-C.
Kleber M.E.
Li H.
Mok Z.Y.
Nakatochi M.
Sapari N.S.
Saxena R.
Stewart A.F.R.
Stolk L.
Tabara Y.
Teh A.L.
Wu Y.
Wu J.-Y.
Zhang Y.
Aits I.
Da Silva Couto Alves A.
Das S.
Dorajoo R.
CHopewell J.
Kim Y.K.
WKoivula R.
Luan J.
Lyytikäinen L.-P.
NNguyen Q.
Pereira M.A.
Postmus I.
TRaitakari O.
Scannell Bryan M.
Scott R.A.
Sorice R.
Tragante V.
Traglia M.
White J.
Yamamoto K.
Zhang Y.
Adair L.S.
Ahmed A.
Akiyama K.
Asif R.
Aung T.
Barroso I.
Bjonnes A.
Braun T.R.
Cai H.
Chang L.-C.
Chen C.-H.
Cheng C.-Y.
Chong Y.-S.
Collins R.
Courtney R.
Davies G.
Delgado G.
Do L.D.
Doevendans P.A.
Gansevoort R.T.
Gao Y.-T.
Grammer T.B.
Grarup N.
Grewal J.
Gu D.
SWander G.
Hartikainen A.-L.
Hazen S.L.
He J.
Heng C.-K.
Hixso E.J.A.
Hofman A.
Hsu C.
Huang W.
Husemoen L.L.N.
Hwang J.-Y.
Ichihara S.
Igase M.
Isono M.
Justesen J.M.
Katsuya T.
GKibriya M.
Kim Y.J.
Kishimoto M.
Koh W.-P.
Kohara K.
Kumari M.
Kwek K.
Lee N.R.
Lee J.
Liao J.
Lieb W.
Liewald D.C.M.
Matsubara T.
Matsushita Y.
Meitinger T.
Mihailov E.
Milani L.
Mills R.
Mononen N.
Müller-Nurasyid M.
Nabika T.
Nakashima E.
Ng H.K.
Nikus K.
Nutile T.
Ohkubo T.
Ohnaka K.
Parish S.
Paternoster L.
Peng H.
Peters A.
TPham S.
Pinidiyapathirage M.J.
Rahman M.
Rakugi H.
Rolandsson O.
Rozario M.A.
Ruggiero D.
Sala C.F.
Sarju R.
Shimokawa K.
Snieder H.
SparsØ T.
Spiering W.
Starr J.M.
Stott D.J.
OStram D.
Sugiyama T.
Szymczak S.
Tang W.H.W.
Tong L.
Trompet S.
Turjanmaa V.
Ueshima H.
Uitterlinden A.G.
Umemura S.
Vaarasmaki M.
Dam R.M.
Van Gilst W.H.
Van Veldhuisen D.J.
Viikari J.S.
Waldenberger M.
Wang Y.
Wang A.
Wilson R.
Wong T.-Y.
Xiang Y.-B.
Yamaguchi S.
Ye X.
Young R.D.
Young T.L.
Yuan J.-M.
Zhou X.
Asselbergs F.W.
Ciullo M.
Clarke R.
Deloukas P.
Franke A.
Paul W.F.
Franks S.
Friedlander Y.
Gross M.D.
Guo Z.
Hansen T.
Jarvelin M.-R.
JØrgensen T.
Jukema J.W.
Kähönen M.
Kajio H.
Kivimaki M.
Lee J.-Y.
Lehtimäki T.
Linneberg A.
Miki T.
Pedersen O.
Samani N.J.
SØrensen T.I.A.
Takayanagi R.
Toniolo D.
Ahsan H.
Allayee H.
Chen Y.-T.
Danesh J.
Deary I.J.
Franco O.H.
Franke L.
THeijman B.
Holbrook J.D.
Isaacs A.
Kim B.-J.
Lin X.
Liu J.
März W.
Metspalu A.
Mohlke K.L.
Sangher K.
Harambir D.
Shu X.-O.
Van Meurs J.B.J.
Vithana E.
Wickremasinghe A.R.
Wijmenga C.
Wolffenbuttel B.H.W.
Yokota M.
Zheng W.
Zhu D.
Vineis P.
[EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A.semantics logo
Kleinjans J.C.S.
McCarthy M.I.
Soong R.
Gieger C.
Scott J.
Teo Y.-Y.
He J.
Elliott P.
Tai E.S.
Van Der Harst P.
Kooner J.S.
Chambers J.C.
Εκδότης: Nature Publishing Group
Ημερομηνία: 2015
Γλώσσα: Αγγλικά
ISSN: 1061-4036
DOI: 10.1038/ng.3405
Άλλο: PubMed ID: 26390057
Περίληψη: We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10 -11 to 5.0 × 10 -21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10 -6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.
Τίτλος πηγής δημοσίευσης: Nature Genetics
Τόμος/Κεφάλαιο: 47
Τεύχος: 11
Σελίδες: 1282-1293
Θεματική Κατηγορία: [EL] Γενετική[EN] Geneticssemantics logo
Αξιολόγηση από ομότιμους (peer reviewed): Ναι
Κάτοχος πνευματικών δικαιωμάτων: © 2015 Nature America, Inc.
Όροι και προϋποθέσεις δικαιωμάτων: All Open Access, Green
Σημειώσεις: 602936; 305280; ISRCTN48489393; FIRB-RBNE08NKH7; 17C-1, 20S-6; 16.54041, 18.54042, 19.7152, 20.54043, 20.7198, 20.7477; 2012-N73002-00; X51001; 12204008, 15790293, 16590433, 16790336, 17390186, 17790381, 18390192, 18590265, 18590587, 18590811, 19590929, 19650188, 19659163, 19790423, 20390184, 20390185, 21390099, 21390223; National Institutes of Health, NIH: P42ES10349, R01CA107431; National Institute of Mental Health, NIMH: R01MH063706, RL1MH083268; National Institute on Aging, NIA: R01AG013196; National Heart, Lung, and Blood Institute, NHLBI: 5RO1HL036310, P01HL076491, P01HL098055, P20HL113452, R01HL085144, R01HL087679, R01HL103866, R01HL103931, R21HL121429; National Human Genome Research Institute, NHGRI; National Cancer Institute, NCI: R01CA055069, R01CA080205, R01CA082729, R01CA144034, R35CA053890, R37CA070867, UM1CA173640, UM1CA182910; Fogarty International Center, FIC: R01TW005596, R01TW008288; National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK: NOT-HG-11-009, P30DK056350, R01DK078150, R01DK082766; National Institute of Environmental Health Sciences, NIEHS: P30ES010126, R01ES021801, R01HL087263, R01HL090682, U01HL072507; U.S. National Library of Medicine, NLM: R01LM010098; National Center for Research Resources, NCRR: P20RR020649; John D. and Catherine T. MacArthur Foundation; National Center for Advancing Translational Sciences, NCATS: UL1TR000439; Velux Stiftung; Fondazione Banco di Sardegna; Compagnia di San Paolo; Hjerteforeningen; University of Oklahoma Health Sciences Center, OUHSC; Sundhed og Sygdom, Det Frie ForskningsrÃ¥d, FSS, DFF; Agency for Health Care Policy and Research, AHCPR: HS06516; Japan Research Foundation for Clinical Pharmacology; Uehara Memorial Foundation; Yrjö Jahnssonin Säätiö; National Center for Global Health and Medicine, NCGM; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Medical Research Council, MRC: G0600331, G0601966, G0700931, G0800270, G0802782, G0902037, MC_U106179471, MC_UU_12013/1, MC_UU_12015/1, MR/K002414/1, MR/K013351/1, MR/K026992/1, MR/L003120/1, MR/L01341X/1; Biotechnology and Biological Sciences Research Council, BBSRC: BB/F019394/1; British Heart Foundation, BHF: RG/07/008/23674; Royal Society; Stroke Association; Age UK; University of Oxford: FS/14/55/30806; European Commission, EC: LSHM-CT-2006-037197; National Medical Research Council, NMRC: Singapore-NMRC/TCR/012-NUHS/2014; National Research Foundation Singapore, NRF; Japan Society for the Promotion of Science, JSPS: 15K05577, 221S0002, 25253059, 25293144, 25670353, 26293149; Ministry of Education, Culture, Sports, Science and Technology, MEXT: 013, H11-Longevity-020, H15-Longevity-005, H16-Kenko-001, H17-Kenkou-007, H17-Longevity-003, H17-Pharmaco-common-003; German-Israeli Foundation for Scientific Research and Development, GIF; Danish Agency for Science and Higher Education; Academia Sinica: 40-05-GMM; Academy of Finland: 117787, 121584, 124282, 126925, 129378, 134309, 286284, 41071; Fondazione Telethon; Fondazione Cariplo; Bundesministerium für Gesundheit, BMG; Suomen Kulttuurirahasto, SKR; Ministerie van Economische Zaken, EZ; Nederlandse Organisatie voor Wetenschappelijk Onderzoek, NWO: 175.010.2007.006, 184.021.007, 22390186, 24591060, 25461127; Core Research for Evolutional Science and Technology, CREST; Ministry of Health, Labour and Welfare, MHLW: 22S-10, 25S-1; Lundbeckfonden; Korea Centers for Disease Control and Prevention, KCDC: 4845-301, 4851-302, 4851-307; Juho Vainion Säätiö; Kyushu University; Novo Nordisk; VetenskapsrÃ¥det, VR; Emil Aaltosen ; Augustinus Fonden; Seventh Framework Programme, FP7; Sixth Framework Programme, FP6; Region Hovedstaden; Sydäntutkimussäätiö; Bundesministerium für Bildung und Frauen, BMBF; Takeda Medical Research Foundation; Tampereen Tuberkuloosisäätiö; Ministeriet Sundhed Forebyggelse; Fondazione CON IL SUD: 2011-PDR-13; National Institute of Biomedical Innovation, NIBIO; Manpei Suzuki Diabetes Foundation; Paavo Nurmen ; Ministry of Internal Affairs and Communications, MIC; Novo Nordisk Fonden, NNF; Tays: 9M048, 9N035.
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