Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Protein modification and maintenance systems as biomarkers of ageing
Δημιουργός/Συγγραφέας:	Vanhooren V. Navarrete Santos A. [EL] Βουτετάκης, Κωνσταντίνος[EN] Voutetakis, Konstantinos Petropoulos I. Libert C. Simm A. [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Friguet B.
Εκδότης:	Elsevier Ireland Ltd
Ημερομηνία:	2015
Γλώσσα:	Αγγλικά
ISSN:	0047-6374
DOI:	10.1016/j.mad.2015.03.009
Άλλο:	PubMed ID: 25846863
Περίληψη:	Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing. Within the frame of the Mark-Age project, the workpackage dedicated to "markers based on proteins and their modifications" has been firstly focused on enzymatic and non-enzymatic post-translational modifications of serum proteins by carbohydrates. The second focus of the workpackage has been directed towards protein maintenance systems that are involved either in protein quality control (ApoJ/Clusterin) or in the removal of oxidatively damaged proteins through degradation and repair (proteasome and methionine sulfoxide reductase systems). This review describes the most relevant features of these protein modifications and maintenance systems, their fate during ageing and/or their implication in ageing and longevity.
Τίτλος πηγής δημοσίευσης:	Mechanisms of Ageing and Development
Τόμος/Κεφάλαιο:	151
Σελίδες:	71-84
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Ageing Biomarkers Protein maintenance Protein modification
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2015 The Authors.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Hybrid Gold, Green
Σημειώσεις:	Seventh Framework Programme, FP7: 200880; European Commission, EC; Seventh Framework Programme, FP7: HEALTH-F4-2008-200880.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο