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Εξειδίκευση τύπου : Άρθρο σε επιστημονικό περιοδικό
Τίτλος: Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: The rhea mother–child cohort (Crete, Greece)
Δημιουργός/Συγγραφέας: Vafeiadi M.
Georgiou V.
Chalkiadaki G.
Rantakokko P.
Kiviranta H.
Karachaliou M.
Fthenou E.
Venihaki M.
Sarri K.
Vassilaki M.
[EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A.semantics logo
Oken E.
Kogevinas M.
Chatzi L.
Εκδότης: Public Health Services, US Dept of Health and Human Services
Ημερομηνία: 2015
Γλώσσα: Αγγλικά
ISSN: 0091-6765
DOI: 10.1289/ehp.1409062
Άλλο: PubMed ID: 25910281
Περίληψη: Prenatal exposure to endocrine-disrupting chemicals such as persistent organic pollutants (POPs) may increase risk of obesity later in life. Objective: We examined the relation of in utero POPs exposure to offspring obesity and cardiometabolic risk factors at 4 years of age in the Rhea mother–child cohort in Crete, Greece (n = 689). Methods: We determined concentrations of polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) in first-trimester maternal serum. We measured child weight, height, waist circumference, skinfold thicknesses, blood pressure (BP), blood levels of lipids, C-reactive protein, and adipokines at 4 years of age. Childhood obesity was defined using age- and sex-specific cut points for body mass index (BMI) as recommended by the International Obesity Task Force. Results: On multivariable regression analyses, a 10-fold increase in HCB was associated with a higher BMI z-score (adjusted β = 0.49; 95% CI: 0.12, 0.86), obesity [relative risk (RR) = 8.14; 95% CI: 1.85, 35.81], abdominal obesity (RR = 3.49; 95% CI: 1.08, 11.28), greater sum of skinfold thickness (β = 7.71 mm; 95% CI: 2.04, 13.39), and higher systolic BP (β = 4.34 mmHg; 95% CI: 0.63, 8.05) at 4 years of age. Prenatal DDE exposure was associated with higher BMI z-score (β = 0.27; 95% CI: 0.04, 0.5), abdominal obesity (RR = 3.76; 95% CI: 1.70, 8.30), and higher diastolic BP (β = 1.79 mmHg; 95% CI: 0.13, 3.46). PCBs were not significantly associated with offspring obesity or cardiometabolic risk factors. Conclusions: Prenatal exposure to DDE and HCB was associated with excess adiposity and higher blood pressure levels in early childhood. Citation: Vafeiadi M, Georgiou V, Chalkiadaki G, Rantakokko P, Kiviranta H, Karachaliou M, Fthenou E, Venihaki M, Sarri K, Vassilaki M, Kyrtopoulos SA, Oken E, Kogevinas M, Chatzi L. 2015. Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: the Rhea mother–child cohort (Crete, Greece).
Τίτλος πηγής δημοσίευσης: Environmental Health Perspectives
Τόμος/Κεφάλαιο: 123
Τεύχος: 10
Σελίδες: 1015-1021
Θεματική Κατηγορία: [EL] Περιβαλλοντική υγεία[EN] Environmental healthsemantics logo
Αξιολόγηση από ομότιμους (peer reviewed): Ναι
Κάτοχος πνευματικών δικαιωμάτων: © 2015, Public Health Services, US Dept of Health and Human Services. All rights reserved.
Όροι και προϋποθέσεις δικαιωμάτων: All Open Access, Bronze, Green
Σημειώσεις: Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD: K24HD069408; Seventh Framework Programme, FP7: 211250, 226285, 308333
Εμφανίζεται στις συλλογές:Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο

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