Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases
Δημιουργός/Συγγραφέας:	[EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki [EL] Βουτετάκης, Κωνσταντίνος[EN] Voutetakis, Konstantinos Kapetanou M. Delitsikou V. Papaevgeniou N. Sakellari M. Lefaki M. Filippopoulou K. [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S.
Εκδότης:	Elsevier Ireland Ltd
Ημερομηνία:	2015
Γλώσσα:	Αγγλικά
ISSN:	1568-1637
DOI:	10.1016/j.arr.2014.12.003
Άλλο:	PubMed ID: 25540941
Περίληψη:	Aging is a natural process accompanied by a progressive accumulation of damage in all constituent macromolecules (nucleic acids, lipids and proteins). Accumulation of damage in proteins leads to failure of proteostasis (or vice versa) due to increased levels of unfolded, misfolded or aggregated proteins and, in turn, to aging and/or age-related diseases. The major cellular proteolytic machineries, namely the proteasome and the lysosome, have been shown to dysfunction during aging and age-related diseases. Regarding the proteasome, it is well established that it can be activated either through genetic manipulation or through treatment with natural or chemical compounds that eventually result to extension of lifespan or deceleration of the progression of age-related diseases. This review article focuses on proteasome activation studies in several species and cellular models and their effects on aging and longevity. Moreover, it summarizes findings regarding proteasome activation in the major age-related diseases as well as in progeroid syndromes.
Τίτλος πηγής δημοσίευσης:	Ageing Research Reviews
Τόμος/Κεφάλαιο:	23
Τεύχος:	PA
Σελίδες:	37-55
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Age-related diseases Aging Longevity Proteasome activation Senescence Ubiquitin-proteasome system
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2014 Elsevier B.V.
Σημειώσεις:	11ΣYN_1_1112; European Commission, EC; European Social Fund, ESF. Cited work from our laboratories has been funded by a Research Funding Program: Thales “GenAge” [ΘAΛHΣ AΠ:10479/3.7.12 MIS380228] to ESG and NC, Thales “MAESTRO” to NC, co-financed by the European Union (European Social Fund – ESF) and Greek national funds through the Operational Program “Education and Lifelong Learning” of the National Strategic Reference Framework (NSRF) , a SYNERGASIA project (11ΣYN_1_1112) and a KRIPIS project to ESG and NC, an IKYDA 2012 fellowship, a Scientific Project funded by John S. Latsis Public Benefit Foundation and a grant from Empirikion Foundation to NC.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο