Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Quality control data of physiological and immunological biomarkers measured in serum and plasma
Δημιουργός/Συγγραφέας:	Jansen E. Beekhof P. Cremers J. Weinberger B. Fiegl S. Toussaint O. Bernhard J. [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Capri M. Franceschi C. Sikora E. Moreno-Villanueva M. Breusing N. Grune T. Bürkle A. Dollé M.E.T.
Εκδότης:	Elsevier Ireland Ltd
Ημερομηνία:	2015
Γλώσσα:	Αγγλικά
ISSN:	0047-6374
DOI:	10.1016/j.mad.2015.06.004
Άλλο:	PubMed ID: 26166476
Περίληψη:	In two work packages of the MARK-AGE project, 37 immunological and physiological biomarkers were measured in 3637 serum, plasma or blood samples in five batches during a period of 4 years.The quality of the serum and plasma samples was very good as judged by the low number of biomarker measurements (only 0.2%) that were rejected because of a high hemolysis, icteria or lipemia of the samples.Using quality control samples, day-to-day and batch variations were determined. The mean inter-assay variation of the five batches were all below 8%, with an average inter-assay coefficient of variation of all biomarkers of 4.0%. Also the precision of the measurements was very good, because all measurements were between 90% and 115% of the defined target values.A possible mix-up of samples was determined by comparison of the extreme testosterone levels of men and women. It was concluded that 3% of the sample identification could be mixed-up.Considering the complex procedure from collection to analysis, including preparation, handling, shipment and storage, of the samples in the MARK-AGE project, both the quality of the samples and the quality of the measurements are very good.
Τίτλος πηγής δημοσίευσης:	Mechanisms of Ageing and Development
Τόμος/Κεφάλαιο:	151
Σελίδες:	54-59
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Biomarkers Hemolysis Quality control
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2015 The Authors.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Hybrid Gold, Green
Σημειώσεις:	Seventh Framework Programme, FP7: 200880; European Commission, EC
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο