Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: A European mother–child study (NewGeneris)
Δημιουργός/Συγγραφέας:	Pedersen M. Mendez M.A. Schoket B. Godschalk R.W. Espinosa A. Landström A. Villanueva C.M. Merlo D.F. Fthenou E. Gracia-Lavedan E. van Schooten F.-J. Hoek G. Brunborg G. Meltzer H.M. Alexander J. Nielsen J.K. Sunyer J. Wright J. Kovács K. de Hoogh K. Gutzkow K.B. Hardie L.J. Chatzi L. Knudsen L.E. Anna L. Ketzel M. Haugen M. Botsivali M. Nieuwenhuijsen M.J. Cirach M. Toledano M.B. Smith R.B. Fleming S. Agramunt S. [EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A. Lukács V. Kleinjans J.C. Segerbäck D. Kogevinas M.
Εκδότης:	Public Health Services, US Dept of Health and Human Services
Ημερομηνία:	2015
Γλώσσα:	Αγγλικά
ISSN:	0091-6765
DOI:	10.1289/ehp.1408613
Άλλο:	PubMed ID: 25626179
Περίληψη:	Background: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk. oBjective: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates. Methods: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006–2010. Cord blood bulky DNA adduct levels were measured by the 32 P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population. results: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England. conclusion: These findings suggest that a combination of factors, including unknown countryspecific factors, influence the bulky DNA adduct levels in neonates.
Τίτλος πηγής δημοσίευσης:	Environmental Health Perspectives
Τόμος/Κεφάλαιο:	123
Τεύχος:	4
Σελίδες:	374-380
Θεματική Κατηγορία:	[EL] Περιβαλλοντική υγεία[EN] Environmental health
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2015, Public Health Services, US Dept of Health and Human Services. All rights reserved
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Bronze, Green
Σημειώσεις:	Seventh Framework Programme, FP7: 211250; Natural Environment Research Council, NERC: NE/E008844/1
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο