Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Development and Evaluation of Stimuli-Responsive Chimeric Nanostructures
Δημιουργός/Συγγραφέας:	Naziris N. Pippa N. [EL] Στέλλας, Δημήτρης[EN] Stellas, Dimitris Chrysostomou V. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos C. Libera M. Trzebicka B.
Εκδότης:	Springer New York LLC
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	1530-9932
DOI:	10.1208/s12249-018-1112-2
Άλλο:	PubMed ID: 30030723
Περίληψη:	Chimeric/mixed stimuli-responsive nanocarriers are promising agents for therapeutic and diagnostic applications, as well as in the combinatorial field of theranostics. Herein, we designed chimeric nanosystems, composed of natural phospholipid and pH-sensitive amphiphilic diblock copolymer, in different molar ratios and assessed the polymer lyotropic effect on their properties. Initially, polymer-grafted bilayers were evaluated for their thermotropic behavior by thermal analysis. Chimeric liposomes were prepared through thin-film hydration and the obtained vesicles were studied by light scattering techniques, to measure their physicochemical characteristics and colloidal stability, as well as by imaging techniques, to elucidate their global and membrane morphology. Finally, in vitro screening of the systems’ toxicity was held. The copolymer effect on the membrane phase transition strongly depended on the pH of the surrounding environment. Chimeric nanoparticles were around and above 100 nm, while electron microscopy revealed occasional morphology diversity, probably affecting the toxicity of the systems. The latter was assessed to be tolerable, while dependent on the nanosystems’ material concentration, polymer concentration, and polymer composition. All experiments suggested that the thermodynamic and biophysical properties of the nanosystems are copolymer-composition- and concentration-dependent, since different amounts of incorporated polymer would produce divergent effects on the lyotropic liquid crystal membrane. Certain chimeric systems can be exploited as advanced drug delivery nanosystems, based on their overall promising profiles.
Τίτλος πηγής δημοσίευσης:	AAPS PharmSciTech
Τόμος/Κεφάλαιο:	19
Τεύχος:	7
Σελίδες:	2971-2989
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	amphiphilic biomaterials biophysics chimeric nanosystems lyotropism pH-responsive
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018, American Association of Pharmaceutical Scientists.
Σημειώσεις:	General Secretariat for Research and Technology, GSRT; Hellenic Foundation for Research and Innovation, HFRI Funding Information This research has been financially supported by the General Secretariat for Research and Technology (GSRT) and the Hellenic Foundation for Research and Innovation (HFRI) (Scholarship Code: 392).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο