Εξειδίκευση τύπου :	Ανακοίνωση σε συνέδριο
Τίτλος:	Fusion of gene and imaging information enhances derivation of robust composite diagnostic biomarkers in the case of melanoma
Δημιουργός/Συγγραφέας:	Valavanis I. Maglogiannis I. [EL] Χατζηιωάννου, Αριστοτέλης[EN] Chatziioannou, Aristotelis
Εκδότης:	CRL Publishing
Ημερομηνία:	2014
Γλώσσα:	Αγγλικά
ISSN:	1472-8915
Περίληψη:	An integrated dataset originating from multi-modal datasets can be used to target underlying causal biological actions that through a systems level process trigger the development of a disease. In this study, we use a dataset related to cutaneous melanoma that has originated from two separate sets (microarray and dermoscopy) and the application of data imputation methods. Our goal is to extract robust diagnostic biomarkers that correspond either to gene expression measurements or imaging features. Using information gain ratio measurements and exploration of Gene Ontology (GO) tree, we identified a set of thirty-two genes with a pivotal role in the molecular regulation of melanoma, and six highly informative imaging features. Selected genes and imaging features were used to construct various classification schemes, including meta-algorithms for combining replicates of the classifiers. Genes in the backstage of low-level biological processes showed to carry higher information content than the macroscopic imaging features, and corresponding classifiers were shown to provide more robust accuracy measurements in unknown data.
Τίτλος πηγής δημοσίευσης:	Engineering Intelligent Systems
Τόμος/Κεφάλαιο:	22
Τεύχος:	3-4
Σελίδες:	205-211
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Classification Correlation Data imputation Dermoscopy Melanoma Microarrays Multi-modal data fusion
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2014 CRL Publishing Ltd.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο