Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Microwave-assisted synthesis of 3,5-disubstituted isoxazoles and evaluation of their anti-ageing activity
Δημιουργός/Συγγραφέας:	[EL] Κουφάκη, Μαρία[EN] Koufaki, Maria Fotopoulou T. Kapetanou M. [EL] Χαιρόπουλος, Γεώργιος Α.[EN] Heropoulos, George A. [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki
Εκδότης:	Elsevier Masson SAS
Ημερομηνία:	2014
Γλώσσα:	Αγγλικά
ISSN:	0223-5234
DOI:	10.1016/j.ejmech.2014.06.046
Άλλο:	PubMed ID: 24996137
Περίληψη:	One-pot uncatalysed microwave-assisted 1,3-dipolar cycloaddition reactions between in situ generated nitrile oxides and alkynes bearing protected antioxidant substituents, were regioselectively afforded 3,5-disubstituted isoxazoles. The yields were moderate, based on the starting aldehydes, while the reaction times were in general shorter than those reported in the literature. The cytoprotective and anti-ageing effect of the final deprotected compounds was evaluated in vitro, on cellular survival following oxidative challenge and in vivo, on organismal longevity using the nematode Caenorhabditis elegans. The activity of the isoxazole analogues depends on the nature and the number of the antioxidant substituents. Analogue 17 bearing a phenolic group and a 6-OH-chroman group is a promising anti-ageing agent, since it increased survival of human primary fibroblasts following treatment with H2O 2 and extended C. elegans lifespan.
Τίτλος πηγής δημοσίευσης:	European Journal of Medicinal Chemistry
Τόμος/Κεφάλαιο:	83
Σελίδες:	508-515
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Χημεία (Γενικά)[EN] Chemistry (General)
Λέξεις-Κλειδιά:	Anti-ageing Antioxidant Caenorhabditiselegans Isoxazole Microwave
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2014 Published by Elsevier Masson SAS.
Σημειώσεις:	National Center for Research Resources, NCRR; College of Environmental Science and Forestry, State University of New York, ESF: 11ΣYN_1_1112; European Commission, EC; European Social Fund, ESF; Seventh Framework Programme, FP7: 10479/3-7-12, 245866, FP7-REGPOT-2009-1. This work was supported by the European Union's Seventh Framework Programme (FP7-REGPOT-2009-1) under grant agreement no. 245866 to MK and GAH as well as by a Research Funding Program : Thales MIS380228 Α.Π. 10479/3-7-12 “GenAge”, co-financed by the European Union (European Social Fund – ESF) and Greek National Funds through the Operational Program “Education and Lifelong Learning” of the National Strategic Reference Framework (NSRF) and a SYNERGASIA project (11ΣYN_1_1112) to ESG and NC. Nematode strains used in this study were provided by the Caenorhabditis Genetics Center, supported by the NIH National Center for Research Resources (NCRR) .
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο