Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother-child study (NewGeneris)
Δημιουργός/Συγγραφέας:	Papadopoulou E. Kogevinas M. Botsivali M. Pedersen M. Besselink H. Mendez M.A. Fleming S. Hardie L.J. Knudsen L.E. Wright J. Agramunt S. Sunyer J. Granum B. Gutzkow K.B. Brunborg G. Alexander J. Meltzer H.M. Brantsæter A.L. Sarri K. Chatzi L. Merlo D.F. Kleinjans J.C. Haugen M.
Εκδότης:	Elsevier B.V.
Ημερομηνία:	2014
Γλώσσα:	Αγγλικά
ISSN:	0048-9697
DOI:	10.1016/j.scitotenv.2014.03.047
Άλλο:	PubMed ID: 24691212
Περίληψη:	Maternal diet can result in exposure to environmental contaminants including dioxins which may influence foetal growth. We investigated the association between maternal diet and birth outcomes by defining a dioxin-rich diet. We used validated food frequency questionnaires to assess the diet of pregnant women from Greece, Spain, United Kingdom, Denmark and Norway and estimated plasma dioxin-like activity by the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR-CALUX®) bioassay in 604 maternal blood samples collected at delivery. We applied reduced rank regression to identify a dioxin-rich dietary pattern based on dioxin-like activity (DR-CALUX®) levels in maternal plasma, and calculated a dioxin-diet score as an estimate of adherence to this dietary pattern. In the five country population, dioxin-diet score was characterised by high consumption of red and white meat, lean and fatty fish, low-fat dairy and low consumption of salty snacks and high-fat cheese, during pregnancy. The upper tertile of the dioxin-diet score was associated with a change in birth weight of - 121. g (95% confidence intervals: - 232, - 10. g) compared to the lower tertile after adjustment for confounders. A small non-significant reduction in gestational age was also observed (- 1.4. days, 95% CI: - 3.8, 1.0. days). Our results suggest that maternal diet might contribute to the exposure of the foetus to dioxins and dioxin-like compounds and may be related to reduced birth weight. More studies are needed to develop updated dietary guidelines for women of reproductive age, aiming to the reduction of dietary exposure to persistent organic pollutants as dioxins and dioxin-like compounds.
Τίτλος πηγής δημοσίευσης:	Science of the Total Environment
Τόμος/Κεφάλαιο:	484
Τεύχος:	1
Σελίδες:	121-128
Θεματική Κατηγορία:	[EL] Περιβαλλοντική υγεία[EN] Environmental health
Λέξεις-Κλειδιά:	Birth weight Cohort study Dietary patterns Dioxins DR-CALUX Pregnancy
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2014 Elsevier B.V.
Σημειώσεις:	151918/S10, Food-CT-2006-036224; 1 UO1 NS 047537-01; National Institute of Neurological Disorders and Stroke, NINDS: U01NS047537; National Institute of Environmental Health Sciences, NIEHS: NO-ES-75558; National Institute for Health Research, NIHR: RP-PG-0407-10044; European Commission, EC: Food-CT-2005-016320; Ministerio de Ciencia e Innovación, MICINN: JCI-2011-09479; Norges Forskningsråd; Utdannings- og forskningsdepartementet, UFD. The NewGeneris (Newborns and Genotoxic exposure risks) study was funded by the European Union (EU Contract Food-CT-2005-016320 ). The study was also supported by grants obtained locally including: the National Institute for Health Research , UK (Programme Grant RP-PG-0407-10044 ), the Norwegian Ministry of Health , the Norwegian Ministry of Education and Research , the Norwegian Research Council / FUGE (Grant No. 151918/S10 ), the EU funded HiWATE (Contract No. Food-CT-2006-036224 ), the US National Institutes of Health / National Institute of Environmental Health Sciences (Contract No. NO-ES-75558 ) and the US National Institutes of Health/NINDS (Grant No. 1 UO1 NS 047537-01 ). HB is employed by BioDetection Systems B.V., Amsterdam, The Netherlands. EP holds the Yggdrasil Grand (Yggdrasil mobility programme 2012–2013) awarded by the Research Council of Norway (219671/F11).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο