Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response in rats
Δημιουργός/Συγγραφέας:	Panagiotidou E. Zerva S. [EL] Μήτσιου, Δήμητρα[EN] Mitsiou, Dimitra J. [EL] Αλέξης, Μιχαήλ Ν.[EN] Alexis, Michael N. Kitraki E.
Ημερομηνία:	2014
Γλώσσα:	Αγγλικά
ISSN:	0022-0795
DOI:	10.1530/JOE-13-0416
Άλλο:	PubMed ID: 24323913
Περίληψη:	Bisphenol A (BPA) is an estrogen-mimicking endocrine disruptor. Early-life exposures to low doses of BPA exert long-lasting effects on animals' reproductive and brain physiology. However, little is known about the effects of BPA on the stress-response system. Given the interaction of sex and stress hormones, we examined the effect of a low perinatal BPA exposure on the function of the hypothalamic-pituitary-adrenal (HPA) axis at rest and upon application of acute stress. Throughout pregnancy and lactation rats received daily 40 μg BPA/kg body weight orally via cornflakes. We studied the effect of this low but chronic exposure to BPA in the male and female offspring at puberty. BPA exposure led to abnormal adrenal histology including reduced zona reticularis especially in male offspring, hyperplasia of zona fasciculata in both sexes, and increased adrenal weight in female offspring. BPA-treated females had increased basal corticosterone and reduced hypothalamic glucocorticoid receptors (GR) levels. Stressed BPA-exposed females exhibited anxiety-like behavioral coping, a less rigorous corticosterone response, and did not downregulate GR in the hypothalamus, compared with control females. BPA-exposed males exhibited a heightened corticosterone stress response compared with females; they also displayed increased pro-opiomelanocortin mRNA levels and retained the prestress levels of pituitary corticotropin-releasing hormone-receptor 1, compared with control males. We found that perinatal chronic exposure to a low dose of BPA perturbs the basal and stress-induced activity of the HPA axis in a sexually dimorphic manner at adolescence. Exposure to BPA might contribute to increased susceptibility to stress-related disorders in later life.
Τίτλος πηγής δημοσίευσης:	Journal of Endocrinology
Τόμος/Κεφάλαιο:	220
Τεύχος:	3
Σελίδες:	207-218
Θεματική Κατηγορία:	[EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Adrenal cortex Bisphenol A Glucocorticoid receptor HPA axis Rat
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2014 Society for Endocrinology.
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Bronze, Green
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο