Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	BRAF vs RAS oncogenes: Are mutations of the same pathway equal? Differential signalling and therapeutic implications
Δημιουργός/Συγγραφέας:	Oikonomou E. Koustas E. Goulielmaki M. [EL] Πίντζας, Αλέξανδρος[EN] Pintzas, Alexander
Εκδότης:	Impact Journals LLC
Ημερομηνία:	2014
Γλώσσα:	Αγγλικά
ISSN:	1949-2553
DOI:	10.18632/oncotarget.2555
Άλλο:	PubMed ID: 25361007
Περίληψη:	As the increased knowledge of tumour heterogeneity and genetic alterations progresses, it exemplifies the need for further personalized medicine in modern cancer management. Here, the similarities but also the differential effects of RAS and BRAF oncogenic signalling are examined and further implications in personalized cancer diagnosis and therapy are discussed. Redundant mechanisms mediated by the two oncogenes as well as differential regulation of signalling pathways and gene expression by RAS as compared to BRAF are addressed. The implications of RAS vs BRAF differential functions, in relevant tumour types including colorectal cancer, melanoma, lung cancer are discussed. Current therapeutic findings and future viewpoints concerning the exploitation of RAS-BRAF-pathway alterations for the development of novel therapeutics and efficient rational combinations, as well as companion tests for relevant markers of response will be evaluated. The concept that drug-resistant cells may also display drug dependency, such that altered dosing may prevent the emergence of lethal drug resistance posed a major therapy hindrance.
Τίτλος πηγής δημοσίευσης:	Oncotarget
Τόμος/Κεφάλαιο:	5
Τεύχος:	23
Σελίδες:	11752-11777
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	BRAF vs KRAS Cancer Differential signalling Rational drug combinations to overcome resistance Targeted therapeutics
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Gold, Green
Σημειώσεις:	09SYN-11-67
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο