Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Therapeutic applications of lipoic acid: A patent review (2011-2014)
Δημιουργός/Συγγραφέας:	[EL] Κουφάκη, Μαρία[EN] Koufaki, Maria
Εκδότης:	Informa Healthcare
Ημερομηνία:	2014
Γλώσσα:	Αγγλικά
ISSN:	1354-3776
DOI:	10.1517/13543776.2014.937425
Άλλο:	PubMed ID: 25101925
Περίληψη:	Introduction: Lipoic acid (LA), a naturally occurring 1,2-dithiolane analog that plays an essential role in mitochondrial bioenergetic reactions, has gained unprecedented attention as nutritional supplement and as therapeutic agent. Moreover, LA conjugates with other pharmacophores represent a promising approach toward the development of multifunctional drugs. Areas covered: The reviewed patent applications from January 2011 to April 2014 include combinations of LA with other bioactive compounds as well as LA conjugates for the treatment of a wide range of clinical conditions. Additionally, some patents disclose methods to overcome the stability problems of LA. Expert opinion: LA is currently in clinical use for the treatment of diabetic neuropathy, while small clinical trials using combinations of LA with known bioactive agents have been undertaken. The use of the LA is hampered by its instability and its rapid metabolism. Thus, formulations containing LA, in a form ensuring its stability and improving its bioavailability, can have important applications as medicines, nutritional supplements or cosmeceuticals. LA hybrids with other pharmacophores endowed with various activities, possess an enormous potential to promote human health and have been the subject of numerous publications and patent applications. Nevertheless, reliable in vivo data and clinical trials are necessary to prove these beneficial effects.
Τίτλος πηγής δημοσίευσης:	Expert Opinion on Therapeutic Patents
Τόμος/Κεφάλαιο:	24
Τεύχος:	9
Σελίδες:	993-1005
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	Cancer Diabetes Inflammation Lipoic acid Lipoic acid conjugates Neurodegenerative diseases Nutraceuticals Pain
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2014 Informa UK, Ltd.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο