Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Micronutrient-gene interactions related to inflammatory/immune response and antioxidant activity in ageing and inflammation. A systematic review
Δημιουργός/Συγγραφέας:	Mocchegiani E. Costarelli L. Giacconi R. Malavolta M. Basso A. Piacenza F. Ostan R. Cevenini E. [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Monti D.
Εκδότης:	Elsevier Ireland Ltd
Ημερομηνία:	2014
Γλώσσα:	Αγγλικά
ISSN:	0047-6374
DOI:	10.1016/j.mad.2013.12.007
Άλλο:	PubMed ID: 24388876
Περίληψη:	Recent longitudinal studies in dietary daily intake in human centenarians have shown that a satisfactory content of some micronutrients within the cells maintain several immune functions, a low grade of inflammation and preserve antioxidant activity. Micronutrients (zinc, copper, selenium) play a pivotal role in maintaining and reinforcing the performances of the immune and antioxidant systems as well as in affecting the complex network of the genes (nutrigenomic) with anti- and pro-inflammatory tasks. Genes of pro- and anti-inflammatory cytokines and some key regulators of trace elements homeostasis, such as Metallothioneins (MT), are involved in the susceptibility to major geriatric disease/disorders. Moreover, the genetic inter-individual variability may affect the nutrients' absorption (nutrigenetic) with altered effects on inflammatory/immune response and antioxidant activity. The interaction between genetic factors and micronutrients (nutrigenomic and nutrigenetic approaches) may influence ageing and longevity because the micronutrients may become also toxic. This review reports the micronutrient-gene interactions in ageing and their impact on the healthy state with a focus on the method of protein-metal speciation analysis. The association between micronutrient-gene interactions and the protein-metal speciation analysis can give a complete picture for a personalized nutrient supplementation or chelation in order to reach healthy ageing and longevity.
Τίτλος πηγής δημοσίευσης:	Mechanisms of Ageing and Development
Τόμος/Κεφάλαιο:	136-137
Σελίδες:	29-49
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Ageing Antioxidant activity Immune system Longevity Zinc/copper/selenium-gene interactions
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2013 Elsevier Ireland Ltd.
Σημειώσεις:	HEALTH-F4-2008-200880; FOOD-2004-506850; 2009-1584108. Supported by INRCA ; European Zincage project (FP6 n. FOOD-2004-506850); European Markage project (FP7 n. HEALTH-F4-2008-200880); Italian Health Ministry (R.F. 154/GR n. 2009-1584108 “My Mind”).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο