Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Persistent organic pollutants exposure during pregnancy, maternal gestational weight gain, and birth outcomes in the mother-child cohort in Crete, Greece (RHEA study)
Δημιουργός/Συγγραφέας:	Vafeiadi M. Vrijheid M. Fthenou E. Chalkiadaki G. Rantakokko P. Kiviranta H. [EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A. Chatzi L. Kogevinas M.
Εκδότης:	Elsevier Ltd
Ημερομηνία:	2014
Γλώσσα:	Αγγλικά
ISSN:	0160-4120
DOI:	10.1016/j.envint.2013.12.015
Άλλο:	PubMed ID: 24389008
Περίληψη:	Background: Persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and pesticides bioaccumulate through the food chain and cross the placenta. POPs are developmental toxicants in animals but the epidemiological evidence on pregnancy outcomes is inconsistent. Maternal gestational weight gain has been recently suggested as a key factor explaining the association between PCBs with lower birth weight. Aims: We examined whether in utero exposure to current low levels of different POPs is associated with fetal growth and gestational age in a mother-child cohort in Crete, Greece (Rhea study), and evaluated specifically whether maternal gestational weight gain may affect this association. Methods: We included 1117 mothers and their newborns from the Rhea study. Mothers were interviewed and blood samples collected during the first trimester of pregnancy. Information on birth outcomes was retrieved from medical records. Concentrations of several PCBs, other organochlorine compounds (dichlorodiphenyl dichloroethene [DDE], dichlorodiphenyl trichloroethane [DDT] and hexachlorobenzene [HCB]) and one polybrominated diphenyl ether congener (tetra-bromodiphenyl ether [BDE-47]), were determined in maternal serum by triple quadrupole mass spectrometry. Multiple linear regression models were used to investigate the associations of birth weight, gestational age, and head circumference with each compound individually on the log10 scale, and with combined exposures through the development of an exposure score. Results: In multivariate models, birth weight was negatively associated with increasing levels of HCB (β = - 161.1 g; 95% CI: - 296.6, - 25.7) and PCBs (β = - 174.1. g; 95% CI: - 332.4, - 15.9); after further adjustment for gestational weight gain these estimates were slightly reduced (β = - 154.3 g; 95% CI: - 300.8, - 7.9 for HCB and β = - 135.7 g; 95% CI: - 315.4, 43.9 for PCBs). Furthermore, in stratified analysis, the association between POPs and birth weight was only observed in women with inadequate or excessive gestational weight gain. Small, negative associations were observed with head circumference while no association was observed with gestational age. Conclusions: The findings suggest that prenatal exposure to PCBs and HCB impairs fetal growth and adds to the growing literature that demonstrates an association between low-level environmental pollutant exposure and fetal growth. Furthermore our results suggest that the association of POPs, maternal gestational weight gain and birth weight is probably more complex than that previously hypothesized.
Τίτλος πηγής δημοσίευσης:	Environment International
Τόμος/Κεφάλαιο:	64
Σελίδες:	116-123
Θεματική Κατηγορία:	[EL] Περιβαλλοντική υγεία[EN] Environmental health [EL] Τοξικολογία[EN] Toxicology. Poisons
Λέξεις-Κλειδιά:	Birth outcomes Cohort studies Gestational weight gain HCB PCBs Persistent organic pollutants
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Όροι και προϋποθέσεις δικαιωμάτων:	All Open Access, Hybrid Gold
Σημειώσεις:	CHICOS-241604, EnviroGenomarkers-226756; Seventh Framework Programme, FP7: 226756, 241604
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο