Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Making sense of OMICS data in population-based environmental health studies
Δημιουργός/Συγγραφέας:	[EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A.
Ημερομηνία:	2013
Γλώσσα:	Αγγλικά
ISSN:	0893-6692
DOI:	10.1002/em.21778
Άλλο:	PubMed ID: 23625801
Περίληψη:	Although experience from the application of OMICS technologies in population-based environmental health studies is still relatively limited, the accumulated evidence shows that it can allow the identification of features (genes, proteins, and metabolites), or sets of such features, which are targeted by particular exposures or correlate with disease risk. Such features or profiles can therefore serve as biomarkers of exposure or disease risk. Blood-based OMIC profiles appear to reflect to some extent events occurring in target tissues and are associated with toxicity or disease and therefore have the potential to facilitate the elucidation of exposure-disease relationships. Further progress in this direction requires better understanding of the significance of exposure-induced network perturbations for disease initiation and progression and the development of a framework that combines agnostic searches with the utilization of prior knowledge, taking account of particular elements which characterize the structure and evolution of complex systems and brings in principles of systems biology. Environ. Mol. Mutagen. 54:468-479, 2013.
Τίτλος πηγής δημοσίευσης:	Environmental and Molecular Mutagenesis
Τόμος/Κεφάλαιο:	54
Τεύχος:	7
Σελίδες:	468-479
Θεματική Κατηγορία:	[EL] Περιβαλλοντική υγεία[EN] Environmental health
Λέξεις-Κλειδιά:	Biomarkers Epigenomics Metabolomics Metabonomics Molecular epidemiology Proteomics Transcriptomics
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2013 Wiley Periodicals, Inc.
Σημειώσεις:	Seventh Framework Programme, FP7: 226756
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο