Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Cubic lyotropic liquid crystals as drug delivery carriers: Physicochemical and morphological studies
Δημιουργός/Συγγραφέας:	Chountoulesi M. Pippa N. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios [EL] Χρυσίνα, Ευαγγελία Δ.[EN] Chrysina, Evangelia D. Forys A. Trzebicka B. Demetzos C.
Εκδότης:	Elsevier B.V.
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	0378-5173
DOI:	10.1016/j.ijpharm.2018.08.003
Άλλο:	PubMed ID: 30121331
Περίληψη:	The self-assembly process of amphiphilic molecules into solvents results in different mesophases, such as inverse cubic and hexagonal that both belong to the wider category of lyotropic liquid crystals. The above mesophases can be further exploited upon the formation of liquid crystalline nanoparticles, cubosomes and hexosomes respectively, which may be utilized as drug delivery nanosystems, exhibiting major advantages. In the present study, liquid crystalline nanoparticles were prepared and evaluated in terms of morphology and physicochemical behavior. The goal of this study is to examine the effect of the different formulation parameters, as well as the effect of the different microenvironmental factors (temperature, ionic strength, pH, serum proteins presence) on their behavior. The physicochemical behavior and the morphology of the systems were investigated by X-Ray Diffraction (XRD), cryogenic-Transmission Electron Microscopy (cryo-TEM), fluorescence spectroscopy and a gamut of light scattering techniques. The formulation process was proved to influence strictly the physicochemical behavior of the prepared nanosystems. They presented colloidal stability over time and upon ionic strength increase, but they were affected by the presence of proteins and presented reversible structure alterations upon temperature increase. Their morphological structure and internal microenvironment, reflected by micropolarity and microfluidity, were also influenced by the formulation parameters.
Τίτλος πηγής δημοσίευσης:	International Journal of Pharmaceutics
Τόμος/Κεφάλαιο:	550
Τεύχος:	1-2
Σελίδες:	57-70
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	Cryogenic-transmission electron microscopy Cubic liquid crystals Cubosomes Light scattering Micropolarity X-ray diffraction
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018 Elsevier B.V.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο