Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Association and Internal Morphology of Self-Assembled HPPhOx/BSA Hybrid Nanoparticles in Aqueous Solutions
Δημιουργός/Συγγραφέας:	[EL] Παπαγιαννόπουλος, Αριστείδης[EN] Papagiannopoulos, Aristeidis Vlassi E. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Houston J.E.
Εκδότης:	American Chemical Society
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	1520-6106
DOI:	10.1021/acs.jpcb.8b04364
Άλλο:	PubMed ID: 29947516
Περίληψη:	We investigate the formation of hybrid polyelectrolyte/protein nanoparticles by associations between aggregates of partially hydrolyzed poly(2-phenyl-2-oxazoline) (HPPhOx) and bovine serum albumin (BSA) in aqueous solutions. Light scattering experiments show that at conditions of low salt, BSA creates interaggregate bridges and increases the size of the HPPhOx nanoparticles. At high salt contents, breaking of aggregates leads to well-defined nanoparticles. The interior of the formed nanoparticles is probed by small-angle neutron scattering. At low salt, diffuse arrangements are observed, whereas at high salt concentration, scattering is dominated by well-defined hydrophobic domains enhanced by the incorporation of BSA. This system shows that the combination of hydrophobic and electrostatic interactions in random-amphiphilic-polyelectrolyte/protein complexes can be used to determine the properties of self-assembled hybrid multifunctional nanoparticles.
Τίτλος πηγής δημοσίευσης:	Journal of Physical Chemistry B
Τόμος/Κεφάλαιο:	122
Τεύχος:	29
Σελίδες:	7426-7435
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018 American Chemical Society.
Σημειώσεις:	European Commission, EC; European Regional Development Fund, FEDER; NSRF 2014-2020 We acknowledge support of this work by the project Advanced Materials and Devices (MIS 5002409) which is implemented under the Action for the Strategic Development on the Research and Technological Sector, funded by the operational program Competitiveness, Entrepreneurship and Innovation (NSRF 2014-2020), and co-financed by Greece and the European Union (European Regional Development Fund).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο