Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Hydrolyzed Poly(2-plenyl-2-oxazoline)s in Aqueous Media and Biological Fluids
Δημιουργός/Συγγραφέας:	Vlassi E. [EL] Παπαγιαννόπουλος, Αριστείδης[EN] Papagiannopoulos, Aristeidis [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	Wiley-VCH Verlag
Ημερομηνία:	2018
Γλώσσα:	Αγγλικά
ISSN:	1022-1352
DOI:	10.1002/macp.201800047
Περίληψη:	Hydrolyzed poly(2-phenyl-2-oxazoline)s (PPhOx) are synthesized by partial hydrolysis of PPhOx in order to produce self-assembling copolymers with chargeable and hydrophobic units. The resulting poly(ethylene imine-co-2-phenyl-2-oxazoline) [P(EI-co-PhOx)] amphiphilic copolymers contain phenyl-oxazoline and ethylene imine segments in a random sequence and their chemical structure is confirmed by 1H NMR and attenuated total reflection-Fourier transform infrared spectroscopy. Static and dynamic light scattering experiments show that in aqueous solutions the random copolymers associate into aggregates of sizes in the range between 50 and 200 nm depending on the solution conditions and hydrophobic content. The positive charge of the nanoaggregates that is caused by protonation of the amine nitrogen is confirmed by zeta potential measurements. Self-assembly in phosphate buffered saline results in large aggregates. The aggregates are proved to interact with fetal bovine serum proteins. This investigation shows that hydrolyzed phenyl oxazoline-based copolymers provide stable amphiphilic nanoparticles able to interact with biological macromolecules for biotechnological and pharmaceutical applications.
Τίτλος πηγής δημοσίευσης:	Macromolecular Chemistry and Physics
Τόμος/Κεφάλαιο:	219
Τεύχος:	13
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Φασματοσκοπία[EN] Spectroscopy
Λέξεις-Κλειδιά:	cationic polyelectrolyte fetal bovine serum hydrolysis light scattering poly(2-phenyl-2-oxazoline)
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Σημειώσεις:	State Scholarships Foundation, IKY: 2016-017-0173-10237
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο