Παρακαλώ χρησιμοποιήστε αυτό το αναγνωριστικό για να παραπέμψετε ή να δημιουργήσετε σύνδεσμο προς αυτό το τεκμήριο: https://hdl.handle.net/10442/17710
Export to:   BibTeX  | EndNote  | RIS
Εξειδίκευση τύπου : Ερευνητικά δεδομένα
Τίτλος: ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses
Δημιουργός: Yilmaz, Canelif
Rogdakis, Thanasis
Latorrata, Alessia
Thanou, Evangelia
Karadima, Eleftheria
Papadimitriou, Eleni
[EL] Σιάπη, Ελένη[EN] Siapi, Elenisemantics logo
Li, Ka Wan
[EL] Κατσίλα, Θεοδώρα[EN] Katsila, Theodorasemantics logo
[EL] Καλογεροπούλου, Θεοδώρα[EN] Calogeropoulou, Theodorasemantics logo
Charalampopoulos, Ioannis
Alexaki, Vasileia Ismini
Ημερομηνία: 2022-03-05
Γλώσσα: Αγγλικά
Περίληψη: Tackling neurodegeneration and neuroinflammation is particularly challenging due to the complexity of central nervous system (CNS) disorders, as well as the limited drug accessibility to the brain. The activation of tropomyosin-related kinase A (TRKA) receptor signaling by the nerve growth factor (NGF) or the neurosteroid dehydroepiandrosterone (DHEA) may combat neurodegeneration and regulate microglial function. In the present study, we synthesized a C-17-spiro-cyclopropyl DHEA derivative (ENT-A010), which was capable of activating TRKA. ENT-A010 protected PC12 cells against serum starvation-induced cell death, dorsal root ganglia (DRG) neurons against NGF deprivation-induced apoptosis and hippocampal neurons against Aβ-induced apoptosis. In addition, ENT-A010 pretreatment partially restored homeostatic features of microglia in the hippocampus of lipopolysaccharide (LPS)-treated mice, enhanced Aβ phagocytosis, and increased Ngf expression in microglia in vitro. In conclusion, the small molecule ENT-A010 elicited neuroprotective effects and modulated microglial function, thereby emerging as an interesting compound, which merits further study in the treatment of CNS disorders.
Θεματική κατηγορία: [EL] Φαρμακευτική[EN] Pharmacy and materia medicasemantics logo
[EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacologysemantics logo
[EL] Βιολογία (Γενικά)[EN] Biology (General)semantics logo
Λέξεις-Κλειδιά: 
DHEA
ENT-A010
hippocampus
microglia
neuroprotection
phagocytosis
ΤRKA
Animals
Dehydroepiandrosterone
Microglia
Signal Transduction
Steroids
Nerve Growth Factor
Neuroprotective Agents
EU Grant: Horizon 2020 Framework Programme, H2020
EU Grant identifier: Marie Skłodowska-Curie grant agreement No 765704
Κάτοχος πνευματικών δικαιωμάτων: Institute of Clinical Chemistry and Laboratory Medicine, University Clinic Carl Gustav Carus, Technische Universität Dresden, Germany
Pharmacology Department, Faculty of Medicine, University of Crete
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Greece
Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece
Center for Neurogenomics and Cognitive Research, Department of Molecular and Cellular Neurobiology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Ηλεκτρονική διεύθυνση με ανοικτή πρόσβαση (link): https://doi.org/10.3390/biom12030424
Εμφανίζεται στις συλλογές:Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο
Άλλα

Αρχεία σε αυτό το τεκμήριο:
Αρχείο Περιγραφή ΣελίδεςΜέγεθοςΜορφότυποςΈκδοσηΆδεια
biomolecules-12-00424-v3.pdfEπιστημονική Δημοσίευση22 σελίδες σελίδες4.29 MBAdobe PDFΔημοσιευμένη/του ΕκδότηccbyThumbnail
Δείτε/ανοίξτε