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https://hdl.handle.net/10442/17833
Εξειδίκευση τύπου : | Άρθρο σε επιστημονικό περιοδικό |
Τίτλος: | Isoflavonoid profiling and estrogen-like activity of four genista species from the greek flora |
Δημιουργός/Συγγραφέας: | Cheilari, Antigoni Vontzalidou, Argyro Makropoulou, Maria Meligova, Aggeliki K Fokialakis, Nikolas Mitakou, Sofia [EL] Αλέξης, Μιχαήλ Ν.[EN] Alexis, Michael N.![semantics logo](/EIE/image/semantics.png) Aligiannis, Nektarios |
Ημερομηνία: | 2020-11-24 |
Γλώσσα: | Αγγλικά |
ISSN: | 1420-3049 |
DOI: | 10.3390/molecules25235507 |
Άλλο: | 33255446 |
Περίληψη: | As part of our ongoing research on phytoestrogens, we investigated the phytochemical profile and estrogen-like activities of eight extracts from the aerial parts of four Genista species of Greek flora using estrogen-responsive cell lines. Ethyl acetate and methanolic extracts of G. acanthoclada, G. depressa,G. hassertiana, and G. millii were obtained with accelerated solvent extraction and their phytochemical profiles were compared using ultra-high-performance liquid chromatography-high-resolution mass spectrometry (uHPLC-HRMS). Fourteen isoflavonoids, previously isolated from G. halacsyi, were used as reference standards for their identification in the extracts. Thirteen isoflavonoids were detected in both extracts of G. acanthoclada and G. hassertiana, while fewer and far fewer were detected in G. millii and G. depressa, respectively. The ethyl acetate extracts of G. hassertiana and G. acanthoclada displayed 2.45- and 1.79-fold higher, respectively, estrogen-like agonist activity in Ishikawa cells compared to MCF-7 cells at pharmacologically relevant concentrations. Both these extracts, but not that of G. depressa, contained mono- and di-O-β-d-glucosides of genistein as well as the aglycone, all three of which are known to display full estrogen-like activity at lower-than-micromolar concentrations. The possibility of using preparations rich in G. hassertiana and/or G. acanthoclada extracts as a potentially safer substitute for low-dose vaginal estrogen for menopausal symptoms is discussed. |
Τίτλος πηγής δημοσίευσης: | Molecules (Basel, Switzerland) |
Τόμος/Κεφάλαιο: | 25 |
Τεύχος: | 23 |
Σελίδες: | 5507 |
Θεματική Κατηγορία: | [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry![semantics logo](/EIE/image/semantics.png) [EL] Κυτταρολογία[EN] Cytology![semantics logo](/EIE/image/semantics.png) |
Λέξεις-Κλειδιά: | Genista acanthoclada Genista depressa Genista hassertiana Genista millii Estrogen - like activiry Isoflavones Biomarkers Cell Proliferation Estrogens Genista Humans Isoflavones MCF-7 Cells Molecular Structure Plant Extracts |
Κάτοχος πνευματικών δικαιωμάτων: | Copyright © 2020 Elsevier B.V. All rights reserved |
Ηλεκτρονική διεύθυνση στον εκδότη (link): | https://www.sciencedirect.com/science/article/abs/pii/S0927775720308554?via%3Dihub |
Ηλεκτρονική διεύθυνση περιοδικού (link) : | https://www.sciencedirect.com/journal/colloids-and-surfaces-a-physicochemical-and-engineering-aspects |
Εμφανίζεται στις συλλογές: | Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο
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