Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework
Δημιουργός/Συγγραφέας:	Cohen, Alan A Kennedy, Brian K Anglas, Ulrich Bronikowski, Anne M Deelen, Joris Dufour, Frédérik Ferbeyre, Gerardo Ferrucci, Luigi Franceschi, Claudio Frasca, Daniela Friguet, Bertrand Gaudreau, Pierrette Gladyshev, Vadim N [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Gorbunova, Vera Gut, Philipp Ivanchenko, Mikhail Legault, Véronique Lemaître, Jean-François Liontis, Thomas Liu, Guang-Hui Liu, Mingxin Maier, Andrea B Nóbrega, Otávio T Olde Rikkert, Marcel G M Pawelec, Graham Rheault, Sylvie Senior, Alistair M Simm, Andreas Soo, Sonja Traa, Annika Ukraintseva, Svetlana Vanhaelen, Quentin Van Raamsdonk, Jeremy M Witkowski, Jacek M Yashin, Anatoliy I Ziman, Robert Fülöp, Tamàs
Εκδότης:	Elsevier
Ημερομηνία:	2020-10
Γλώσσα:	Αγγλικά
ISSN:	00476374
DOI:	10.1016/j.mad.2020.111316
Άλλο:	32693105
Περίληψη:	At a recent symposium on aging biology, a debate was held as to whether or not we know what biological aging is. Most of the participants were struck not only by the lack of consensus on this core question, but also on many basic tenets of the field. Accordingly, we undertook a systematic survey of our 71 participants on key questions that were raised during the debate and symposium, eliciting 37 responses. The results confirmed the impression from the symposium: there is marked disagreement on the most fundamental questions in the field, and little consensus on anything other than the heterogeneous nature of aging processes. Areas of major disagreement included what participants viewed as the essence of aging, when it begins, whether aging is programmed or not, whether we currently have a good understanding of aging mechanisms, whether aging is or will be quantifiable, whether aging will be treatable, and whether many non-aging species exist. These disagreements lay bare the urgent need for a more unified and cross-disciplinary paradigm in the biology of aging that will clarify both areas of agreement and disagreement, allowing research to proceed more efficiently. We suggest directions to encourage the emergence of such a paradigm.
Τίτλος πηγής δημοσίευσης:	Mechanisms of ageing and development
Τόμος/Κεφάλαιο:	191
Σελίδες:	111316
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Aged Aging interventions Aging mechanisms Aging paradigm Biology of aging Epidemiology of aging Evolution of aging Philosophy of science Humans Aging Biomedical Research Consensus
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Elsevier B.V. All rights reserved
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://pubmed.ncbi.nlm.nih.gov/32693105/
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/mechanisms-of-ageing-and-development
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο