Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Development and study of nanoemulsions and nanoemulsion-based hydrogels for the encapsulation of lipophilic compounds
Δημιουργός/Συγγραφέας:	Demisli, Sotiria Mitsou, Evgenia [EL] Πλέτσα, Βασιλική[EN] Pletsa, Vassiliki [EL] Ξενάκης, Αριστοτέλης[EN] Xenakis, Aristotelis [EL] Παπαδημητρίου, Βασιλική[EN] Papadimitriou, Vassiliki
Εκδότης:	MDPI
Ημερομηνία:	2020-12-09
Γλώσσα:	Αγγλικά
ISSN:	2079-4991
DOI:	10.3390/nano10122464
Άλλο:	33317080
Περίληψη:	Biocompatible nanoemulsions and nanoemulsion-based hydrogels were formulated for the encapsulation and delivery of vitamin D3 and curcumin. The aforementioned systems were structurally studied applying dynamic light scattering (DLS), electron paramagnetic resonance (EPR) spectroscopy and viscometry. In vitro studies were conducted using Franz diffusion cells to investigate the release of the bioactive compounds from the nanocarriers. The cytotoxicity of the nanoemulsions was investigated using the thiazolyl blue tetrazolium bromide (MTT) cell proliferation assay and RPMI 2650 nasal epithelial cells as in vitro model. DLS measurements showed that vitamin D3 and curcumin addition in the dispersed phase of the nanoemulsions caused an increase in the size of the oil droplets from 78.6 ± 0.2 nm to 83.6 ± 0.3 nm and from 78.6 ± 0.2 nm to 165.6 ± 1.0 nm, respectively. Loaded nanoemulsions, in both cases, were stable for 60 days of storage at 25 °C. EPR spectroscopy revealed participation of vitamin D3 and curcumin in the surfactants monolayer. In vitro release rates of both lipophilic compounds from the nanoemulsions were comparable to the corresponding ones from the nanoemulsion-based hydrogels. The developed o/w nanoemulsions did not exhibit cytotoxic effect up to the concentration threshold of 1 mg/mL in the cell culture medium.
Τίτλος πηγής δημοσίευσης:	Nanomaterials (Basel, Switzerland)
Τόμος/Κεφάλαιο:	10
Τεύχος:	12
Σελίδες:	2464
Θεματική Κατηγορία:	[EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	DLS EPR Cell viability Curcumin Hydrogels In vitro release Nanoemulsions Vitamin D3
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2079-4991/10/12/2464
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/journal/nanomaterials
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο