Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Blood transcriptome response to environmental metal exposure reveals potential biological processes related to Alzheimer's disease
Δημιουργός/Συγγραφέας:	Krauskopf, Julian Bergdahl, Ingvar A Johansson, Anders Palli, Domenico Lundh, Thomas [EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A. de Kok, Theo M Kleinjans, Jos C
Ημερομηνία:	2020
Γλώσσα:	Αγγλικά
ISSN:	2296-2565
DOI:	10.3389/fpubh.2020.557587
Άλλο:	33194959
Περίληψη:	Alzheimer's disease (AD) is a neurodegenerative disease which is manifested by a progressive and irreversible decline of cognition, memory loss, a shortened attention span, and changes in personality. Aging and genetic pre-dispositions, particularly the presence of a specific form of apolipoprotein E (APOE), are main risk factors of sporadic AD; however, a large body of evidence has shown that multiple environmental factors, including exposure to toxic metals, increase the risk for late onset AD. Lead (Pb) and cadmium (Cd) are ubiquitous toxic metals with a wide range of applications resulting in global distribution in the environment and exposure of all living organisms on earth. In addition to being classified as carcinogenic (Cd) and possibly carcinogenic (Pb) to humans by the International Agency for Research on Cancer, both compounds disrupt metal homeostasis and can cause toxic responses at the cellular and organismal levels. Pb toxicity targets the central nervous system and evidence for that has emerged also for Cd. Recent epidemiological studies show that both metals possibly are etiological factors of multiple neurodegenerative diseases, including Alzheimer's disease (AD). To further explore the association between metal exposure and AD risk we applied whole transcriptome gene expression analysis in peripheral blood leukocytes (PBLs) from 632 subjects of the general population, taken from the EnviroGenomarkers project. We used linear mixed effect models to associate metal exposure to gene expression after adjustment for gender, age, BMI, smoking, and alcohol consumption. For Pb exposure only few associations were identified, including a downregulation of the human eukaryotic translation initiation factor 5 (eIF5). In contrast, Cd exposure, particularly in males, revealed a much stronger transcriptomic response, featuring multiple pathways related to pathomolecular mechanisms of AD, such as endocytosis, neutrophil degranulation, and Interleukin-7 signaling. A gender stratified analysis revealed that the Cd responses were male-specific and included a downregulation of the APOE gene in men. This exploratory study revealed novel hypothetical findings which might contribute to the understanding of the neurotoxic effects of chronic Pb and Cd exposure and possibly improve our knowledge on the molecular mechanisms linking metal exposure to AD risk.
Τίτλος πηγής δημοσίευσης:	Frontiers in public health
Τόμος/Κεφάλαιο:	8
Σελίδες:	557587
Θεματική Κατηγορία:	[EL] Ιατρική[EN] Medicine [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Χημεία (Γενικά)[EN] Chemistry (General) [EL] Γενετική[EN] Genetics [EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	APOE Alzheimer's disease Gene expression Metals Microarray Transcriptomics Environmental Exposure Female Humans Male Transcriptome Alzheimer Disease Biological Phenomena Neurodegenerative Diseases
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Frontiers Media S.A. All rights reserved
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.frontiersin.org/journals/public-health
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο