Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	An intrinsic role of IL-33 in Treg cell-mediated tumor immunoevasion
Δημιουργός/Συγγραφέας:	Hatzioannou, Aikaterini Banos, Aggelos Sakelaropoulos, Theodore Fedonidis, Constantinos Vidali, Maria-Sophia Köhne, Maren Händler, Kristian Boon, Louis Henriques, Ana Koliaraki, Vasiliki [EL] Γεωργιάδης, Παναγιώτης[EN] Georgiadis, Panagiotis Zoidakis, Jerome Termentzi, Aikaterini Beyer, Marc Chavakis, Triantafyllos Boumpas, Dimitrios Tsirigos, Aristotelis Verginis, Panayotis
Ημερομηνία:	2020-01
Γλώσσα:	Αγγλικά
ISSN:	1529-2908 1529-2916
DOI:	10.1038/s41590-019-0555-2
Άλλο:	31844326
Περίληψη:	Regulatory T (Treg) cells accumulate into tumors, hindering the success of cancer immunotherapy. Yet, therapeutic targeting of Treg cells shows limited efficacy or leads to autoimmunity. The molecular mechanisms that guide Treg cell stability in tumors remain elusive. In the present study, we identify a cell-intrinsic role of the alarmin interleukin (IL)-33 in the functional stability of Treg cells. Specifically, IL-33-deficient Treg cells demonstrated attenuated suppressive properties in vivo and facilitated tumor regression in a suppression of tumorigenicity 2 receptor (ST2) (IL-33 receptor)-independent fashion. On activation, Il33-/- Treg cells exhibited epigenetic re-programming with increased chromatin accessibility of the Ifng locus, leading to elevated interferon (IFN)-γ production in a nuclear factor (NF)-κB-T-bet-dependent manner. IFN-γ was essential for Treg cell defective function because its ablation restored Il33-/- Treg cell-suppressive properties. Importantly, genetic ablation of Il33 potentiated the therapeutic effect of immunotherapy. Our findings reveal a new and therapeutically important intrinsic role of IL-33 in Treg cell stability in cancer.
Τίτλος πηγής δημοσίευσης:	Nature immunology
Τόμος/Κεφάλαιο:	21
Τεύχος:	1
Σελίδες:	75-85
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Κυτταρολογία[EN] Cytology [EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Ανοσολογία[EN] Immunology
Λέξεις-Κλειδιά:	Animals Cell Line, Tumor Interferon-gamma Interleukin-1 Receptor-Like 1 Protein Interleukin-33 Melanoma, Experimental Mice Mice, Inbred C57BL Mice, Knockout NF-kappa B T-Lymphocytes, Regulatory Tumor Escape
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.nature.com/articles/s41590-019-0555-2
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.nature.com/ni/
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο