Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Prevalence and loads of torquetenovirus in the european MARK-AGE study population
Δημιουργός/Συγγραφέας:	Giacconi, Robertina Maggi, Fabrizio Macera, Lisa Spezia, Pietro Giorgio Pistello, Mauro Provinciali, Mauro Piacenza, Francesco Basso, Andrea Bürkle, Alexander Moreno-Villanueva, María Dollé, Martijn E T Jansen, Eugène Grune, Tilman Stuetz, Wolfgang [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Schön, Christiane Bernhardt, Jürgen Grubeck-Loebenstein, Beatrix Sikora, Ewa Dudkowska, Magdalena Janiszewska, Dorota Toussaint, Olivier Debacq-Chainiaux, Florence Franceschi, Claudio Capri, Miriam Hervonen, Antti Hurme, Mikko Slagboom, Eline Breusing, Nicolle Mocchegiani, Eugenio Malavolta, Marco
Ημερομηνία:	2020-09-25
Γλώσσα:	Αγγλικά
ISSN:	1079-5006 1758-535X
DOI:	10.1093/gerona/glz293
Άλλο:	31838498
Περίληψη:	Torquetenovirus (TTV) viremia has been associated with increased mortality risk in the elderly population. This work aims to investigate TTV viremia as a potential biomarker of immunosenescence. We compared levels of circulating TTV in 1813 participants of the MARK-AGE project, including human models of delayed (offspring of centenarians [GO]) and premature (Down syndrome [DS]) immunosenescence. The TTV load was positively associated with age, cytomegalovirus (CMV) antibody levels, and the Cu/Zn ratio and negatively associated with platelets, total cholesterol, and total IgM. TTV viremia was highest in DS and lowest in GO, with intermediate levels in the SGO (spouses of GO) and RASIG (Randomly Recruited Age-Stratified Individuals From The General Population) populations. In the RASIG population, TTV DNA loads showed a slight negative association with CD3+T-cells and CD4+T-cells. Finally, males with ≥4log TTV copies/mL had a higher risk of having a CD4/CD8 ratio<1 than those with lower viremia (odds ratio [OR] = 2.85, 95% confidence interval [CI]: 1.06-7.62), as well as reduced CD3+ and CD4+T-cells compared to males with lower replication rates (<4log), even after adjusting for CMV infection. In summary, differences in immune system preservation are reflected in the models of delayed and premature immunosenescence, displaying the best and worst control over TTV replication, respectively. In the general population, TTV loads were negatively associated with CD4+ cell counts, with an increased predisposition for an inverted CD4/CD8 ratio for individuals with TTV loads ≥4log copies/mL, thus promoting an immune risk phenotype.
Τίτλος πηγής δημοσίευσης:	The journals of gerontology. Series A, Biological sciences and medical sciences
Τόμος/Κεφάλαιο:	75
Τεύχος:	10
Σελίδες:	1838-1845
Θεματική Κατηγορία:	[EL] Κυτταρολογία[EN] Cytology [EL] Ιατρική[EN] Medicine [EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Ανοσολογία[EN] Immunology [EL] Βιοχημεία[EN] Biochemistry [EL] Ιολογία[EN] Virology [EL] Μικροβιολογία[EN] Microbiology
Λέξεις-Κλειδιά:	Aging CD4/CD8 ratio Down syndrome Immunosenescence TTV Adult Age Factors Aged Cross-Sectional Studies Cytomegalovirus DNA Virus Infections Down Syndrome Female Humans Immunosenescence Lymphocyte Count Male Middle Aged Prevalence Torque teno virus Viral Load Viremia
Τοπική Κάλυψη:	Europe
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://academic.oup.com/biomedgerontology/article/75/10/1838/5678083
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://academic.oup.com/biomedgerontology
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο