Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Development of a microemulsion for encapsulation and delivery of gallic acid. The role of chitosan
Δημιουργός/Συγγραφέας:	Mitsou, Evgenia [EL] Πλέτσα, Βασιλική[EN] Pletsa, Vassiliki [EL] Σωτηρούδης, Γιώργος[EN] Sotiroudis, Georgios Panine, Pierre [EL] Ζουμπανιώτη, Μαρία[EN] Zoumpanioti, Maria [EL] Ξενάκης, Αριστοτέλης[EN] Xenakis, Aristotelis
Εκδότης:	Springer
Ημερομηνία:	2020-06
Γλώσσα:	Αγγλικά
ISSN:	09277765
DOI:	10.1016/j.colsurfb.2020.110974
Άλλο:	32208193
Περίληψη:	A novel water-in-oil (W/O) microemulsion based on natural oils, namely extra virgin olive oil (EVOO) and sunflower oil (SO), in the presence of non-ionic surfactants was successfully formulated. The novel microemulsion was used as a carrier for gallic acid (GA) to assure its protection and efficacy upon nasal administration. The work presents evidence that this microemulsion can be used as a nasal formulation for the delivery of polar antioxidants, especially, after incorporation of chitosan (CH) in its aqueous phase. The structure of the system was studied by Small Angle X-ray Scattering (SAXS), Dynamic Light Scattering (DLS) and Electron Paramagnetic Resonance (EPR) spectroscopy techniques. By the addition of CH, the diameter of the microemulsion remained unaltered at 47 nm whereas after the incorporation of GA, micelles with 51 nm diameter were detected. The dynamic properties of the surfactant monolayer were affected by both the incorporation of CH and GA. Moreover, the antioxidant activity of the latter remained unaltered (99 %). RPMI 2650 cell line was used as the in vitro model for cell viability and for GA nasal epithelial transport studies after microemulsion administration. The results suggested that the nasal epithelial permeation of GA was enhanced, 3 h post administration, by the presence of 0.2 % v/v microemulsion in the culture medium. However, the concentration of the transported antioxidant in the presence of CH was higher indicating the polymer's effect on the transport of the GA. The study revealed that nasal administration of hydrophilic antioxidants could be used as an alternative route besides oral administration.
Τίτλος πηγής δημοσίευσης:	Colloids and surfaces. B, Biointerfaces
Τόμος/Κεφάλαιο:	190
Σελίδες:	110974
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Ιατρική[EN] Medicine [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	Antioxidant Biocompatible oils Chitosan Microemulsion Nasal administration Antineoplastic Agents Antioxidants Cell Line, Tumor Cell Proliferation Cell Survival Chitosan Drug Carriers Drug Screening Assays, Antitumor Emulsions Gallic Acid Humans Micelles Particle Size Reactive Oxygen Species Surface Properties Drug Delivery Systems
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Elsevier B.V. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/abs/pii/S0927776520302046?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/colloids-and-surfaces-b-biointerfaces
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο