Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	The dietary triterpenoid 18α-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway
Δημιουργός/Συγγραφέας:	Lefaki, Maria Papaevgeniou, Nikoletta Tur, Josep A Vorgias, Constantinos E Sykiotis, Gerasimos P [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki
Ημερομηνία:	2020-01
Γλώσσα:	Αγγλικά
ISSN:	22132317
DOI:	10.1016/j.redox.2019.101317
Άλλο:	31505326
Περίληψη:	18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid that has been shown to activate the nuclear factor (erythroid-derived-2)-like 2 (Nrf2), the main transcription factor that orchestrates the cellular antioxidant response, in both cellular and organismal context. Although various beneficial properties of 18α-GA have been revealed, including its anti-oxidation and anti-aging activity, its possible protective effect against DNA damage has never been addressed. In this study, we investigated the potential beneficial properties of 18α-GA against DNA damage induced by mitomycin C (MMC) treatment. Using human primary fibroblasts exposed to MMC following pre-treatment with 18α-GA, we reveal an Nrf2-mediated protective effect against MMC-induced cell death that depends on extracellular signal-regulated kinase (ERK) signaling. In total, our results reveal an additional beneficial effect of the Nrf2 activator 18α-GA, suggesting that this important phytochemical compound is a potential candidate in preventive and/or therapeutic schemes against conditions (such as aging) or diseases that are characterized by both oxidative stress and DNA damage.
Τίτλος πηγής δημοσίευσης:	Redox biology
Τόμος/Κεφάλαιο:	28
Σελίδες:	101317
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Κυτταρολογία[EN] Cytology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	18α–Glycyrrhetinic acid DNA damage ERK pathway Mitomycin C Nrf2 Phytochemicals Apoptosis Cell Line DNA Damage Fibroblasts Gene Expression Regulation Glycyrrhetinic Acid Humans MAP Kinase Signaling System Mitomycin NF-E2-Related Factor 2 Oxidative Stress Reactive Oxygen Species
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2019 Published by Elsevier B.V.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S2213231719308602?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/redox-biology
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο