Εξειδίκευση τύπου :	Κεφάλαιο βιβλίου
Τίτλος:	We are what we eat: Ubiquitin–Proteasome System (UPS) modulation through dietary products
Δημιουργός/Συγγραφέας:	Panagiotidou, Eleni [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki
Επιμελητής έκδοσης:	Barrio, Rosa Sutherland, James D. Rodriguez, Manuel S.
Εκδότης:	Springer
Ημερομηνία:	2020
Γλώσσα:	Αγγλικά
ISBN:	978-3-030-38265-0 978-3-030-38266-7
ISSN:	0065-2598 2214-8019
DOI:	10.1007/978-3-030-38266-7_15
Περίληψη:	During lifetime, the molecular mechanisms that are responsible for cellular defense against adverse conditions such as oxidative and heat stress tend to be less efficient, thus gradually leading to the natural phenomenon of aging. Aging is linked to increased oxidative stress and is characterized by the accumulation of damaged macromolecules. The accumulation of oxidized and misfolded proteins is also accusable for various neurodegenerative pathologies thatare linked to aging. Among self-defense mechanisms of cells, proteostasis network isresponsible for the proper biogenesis/folding of proteins and their elimination through proteolysis. The ubiquitin-proteasome system (UPS) is the major proteolytic mechanism that has attracted the interest of many researchers as an antiaging target. Interestingly, many natural compounds have been identified as potent UPS activators. Given that diet is a manageable environmental factor that affects aging, consumption of natural dietary products that may potentially enhance the UPS function, would contribute to increased health span and delayed onset or progression of age-related disorders. Herein, we summarize natural compounds and extracts derived from edible products that have exhibited antiaging and anti-aggregation properties and the beneficial properties have been linked to the UPS modulation
Τίτλος πηγής δημοσίευσης:	Proteostasis and Disease: From Basic Mechanisms to Clinics
Τόμος/Κεφάλαιο:	1233
Σελίδες:	329-348
Σειρά δημοσίευσης:	Advances in Experimental Medicine and Biology
Θεματική Κατηγορία:	[EL] Ιατρική (Γενικά)[EN] Medicine (General) [EL] Κυτταρολογία[EN] Cytology [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Ubiquitin-proteasome system (UPS) Proteasome modulation Aging Age-related diseases Dietary compounds
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Springer Nature Switzerland AG
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://link.springer.com/chapter/10.1007/978-3-030-38266-7_15
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://link.springer.com/book/10.1007/978-3-030-38266-7
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο