Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)
Δημιουργός/Συγγραφέας:	Baliou, Stella Kyriakopoulos, Anthony M [EL] Σπαντίδος, Δημήτριος Α.[EN] Spandidos, Demetrios A. [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis
Ημερομηνία:	2020-09
Γλώσσα:	Αγγλικά
ISSN:	1019-6439 1791-2423
DOI:	10.3892/ijo.2020.5100
Άλλο:	32705269
Περίληψη:	For one century, taurine is considered as an end product of sulfur metabolism. In this review, we discuss the beneficial effect of taurine, its haloamines and taurine upregulated gene 1 (TUG1) long non‑coding RNA (lncRNA) in both cancer and inflammation. We outline how taurine or its haloamines (N‑Bromotaurine or N‑Chlorotaurine) can induce robust and efficient responses against inflammatory diseases, providing insight into their molecular mechanisms. We also provide information about the use of taurine as a therapeutic approach to cancer. Taurine can be combined with other chemotherapeutic drugs, not only mediating durable responses in various malignancies, but also circumventing the limitations met from chemotherapeutic drugs, thus improving the therapeutic outcome. Interestingly, the lncRNA TUG1 is regarded as a promising therapeutic approach, which can overcome acquired resistance of cancer cells to selected strategies. In this regard, we can translate basic knowledge about taurine and its TUG1 lncRNA into potential therapeutic options directed against specific oncogenic signaling targets, thereby bridging the gap between bench and bedside.
Τίτλος πηγής δημοσίευσης:	International journal of oncology
Τόμος/Κεφάλαιο:	57
Τεύχος:	3
Σελίδες:	631-664
Θεματική Κατηγορία:	[EL] Ιατρική (Γενικά)[EN] Medicine (General) [EL] Κυτταρολογία[EN] Cytology [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Taurine Taurine haloamines Taurine upregulated gene 1 ncRNA Inflammation Cancer Animals Anti-Inflammatory Agents Antineoplastic Agents Cell Proliferation Disease Models, Animal Disease Progression Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Humans Inflammation Prognosis RNA, Long Noncoding
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 by the authors
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.spandidos-publications.com/10.3892/ijo.2020.5100
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.spandidos-publications.com/ijo
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο