Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases
Δημιουργός/Συγγραφέας:	Xie, Kan Kapetanou, Marianna Sidiropoulou, Kyriaki Bano, Daniele [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Djordjevic, Aleksandra Mladenovic Ehninger, Dan
Εκδότης:	Elsevier
Ημερομηνία:	2020-12
Γλώσσα:	Αγγλικά
ISSN:	00476374
DOI:	10.1016/j.mad.2020.111364
Άλλο:	32991920
Περίληψη:	Several laboratory animal models have shown that dietary energy restriction (ER) can promote longevity and improve various health aspects in old age. However, whether the entire spectrum of ER-induced short- and long-term physiological and metabolic adaptions is translatable to humans remains to be determined. In this review article, we present recent evidence towards the elucidation of the impact of ER on brain physiology and in age-related neurodegenerative diseases. We also discuss modulatory influences of ER on metabolism and overall on human health, limitations of current experimental designs as well as future perspectives for ER trials in humans. Finally, we summarize signaling pathways and processes known to be affected by both aging and ER with a special emphasis on the link between ER and cellular proteostasis.
Τίτλος πηγής δημοσίευσης:	Mechanisms of ageing and development
Τόμος/Κεφάλαιο:	192
Σελίδες:	111364
Θεματική Κατηγορία:	[EL] Ιατρική (Γενικά)[EN] Medicine (General) [EL] Κυτταρολογία[EN] Cytology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Aging Brain Dietary energy restriction Metabolism Neurodegeneration Animals Brain Caloric Restriction Cognitive Aging Humans Longevity Proteostasis Signal Transduction Neurodegenerative Diseases
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Elsevier B.V. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/abs/pii/S0047637420301603?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/mechanisms-of-ageing-and-development
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο