Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Structural study of (Hydroxypropyl) methyl cellulose microemulsion-based gels used for biocompatible encapsulations
Δημιουργός/Συγγραφέας:	Vassiliadi, Evdokia Mitsou, Evgenia Avramiotis, Spyridon [EL] Χώχος, Χρήστος[EN] Chochos, Christos Pirolt, Franz Medebach, Martin Glatter, Otto [EL] Ξενάκης, Αριστοτέλης[EN] Xenakis, Aristotelis [EL] Ζουμπανιώτη, Μαρία[EN] Zoumpanioti, Maria
Ημερομηνία:	2020-11-05
Γλώσσα:	Αγγλικά
ISSN:	2079-4991
DOI:	10.3390/nano10112204
Άλλο:	33167302
Περίληψη:	(Hydroxypropyl)methyl cellulose (HPMC) can be used to form gels integrating a w/o microemulsion. The formulation in which a microemulsion is mixed with a hydrated HPMC matrix has been successfully used as a carrier of biocompatible ingredients. However, little is known about the structure of these systems. To elucidate this, scanning electron microscopy was used to examine the morphology and the bulk of the microemulsion-based gels (MBGs) and small-angle X-ray scattering to clarify the structure and detect any residual reverse micelles after microemulsion incorporation in the gel. Electron paramagnetic resonance spectroscopy was applied using spin probes to investigate the polar and non-polar areas of the gel. Furthermore, the enzyme-labelling technique was followed to investigate the location of an enzyme in the matrix. A structural model for HPMC matrix is proposed according to which, although a w/o microemulsion is essential to form the final gel, no microemulsion droplets can be detected after incorporation in the gel. Channels are formed by the organic solvent (oil), which are coated by surfactant molecules and a water layer in which the enzyme can be hosted.
Τίτλος πηγής δημοσίευσης:	Nanomaterials (Basel, Switzerland)
Τόμος/Κεφάλαιο:	10
Τεύχος:	11
Σελίδες:	2204
Θεματική Κατηγορία:	[EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοτεχνολογία[EN] Biotechnology [EL] Οργανική χημεία[EN] Organic chemistry
Λέξεις-Κλειδιά:	(hydroxypropyl)methyl cellulose (HPMC) Electron paramagnetic resonance (EPR) Lipase Scanning electron microscopy (SEM) Small angle X-ray scattering (SAXS)
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2079-4991/10/11/2204
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/journal/nanomaterials
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο