Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	A proof-of-concept study on the therapeutic potential of au nanoparticles radiolabeled with the alpha-emitter actinium-225
Δημιουργός/Συγγραφέας:	Salvanou, Evangelia-Alexandra [EL] Στέλλας, Δημήτρης[EN] Stellas, Dimitris Tsoukalas, Charalampos Mavroidi, Barbara Paravatou-Petsotas, Maria Kalogeropoulos, Nikolaos Xanthopoulos, Stavros Denat, Franck Laurent, Gautier Bazzi, Rana Roux, Stephane Bouziotis, Penelope
Ημερομηνία:	2020-02-21
Γλώσσα:	Αγγλικά
ISSN:	1999-4923
DOI:	10.3390/pharmaceutics12020188
Άλλο:	32098286
Περίληψη:	Actinium-225 (225Ac) is receiving increased attention for its application in targeted radionuclide therapy, due to the short range of its emitted alpha particles in conjunction with their high linear energy transfer, which lead to the eradication of tumor cells while sparing neighboring healthy tissue. The objective of our study was the evaluation of a gold nanoparticle radiolabeled with 225Ac as an injectable radiopharmaceutical form of brachytherapy for local radiation treatment of cancer. Au@TADOTAGA was radiolabeled with 225Ac at pH 5.6 (30 min at 70 °C), and in vitro stability was evaluated. In vitro cytotoxicity was assessed in U-87 MG cancer cells, and in vivo biodistribution was performed by intravenous and intratumoral administration of [225Ac]225Ac-Au@TADOTAGA in U-87 MG tumor-bearing mice. A preliminary study to assess therapeutic efficacy of the intratumorally-injected radio-nanomedicine was performed over a period of 22 days, while the necrotic effect on tumors was evaluated by a histopathology study. We have shown that [225Ac]225Ac-Au@TADOTAGA resulted in the retardation of tumor growth after its intratumoral injection in U87MG tumor-bearing mice, even though very low activities were injected per mouse. This gold nanoparticle radiopharmaceutical could be applied as an unconventional brachytherapy in injectable form for local radiation treatment of cancer.
Τίτλος πηγής δημοσίευσης:	Pharmaceutics
Τόμος/Κεφάλαιο:	12
Τεύχος:	2
Σελίδες:	188
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Κυτταρολογία[EN] Cytology [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Actinium-225 Alpha emitters Brachytherapy Cancer therapy Gold nanoparticles Radiolabeling
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 MDPI (Basel, Switzerland)
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/1999-4923/12/2/188
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/journal/pharmaceutics
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο