Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	pHEMA@AGMNA-1: A novel material for the development of antibacterial contact lens
Δημιουργός/Συγγραφέας:	Rossos, A K Banti, C N Kalampounias, A G Papachristodoulou, C Kordatos, K [EL] Ζουμπουλάκης, Παναγιώτης[EN] Zoumpoulakis, Panagiotis Mavromoustakos, T Kourkoumelis, N Hadjikakou, S K
Ημερομηνία:	2020-06
Γλώσσα:	Αγγλικά
ISSN:	09284931
DOI:	10.1016/j.msec.2020.110770
Άλλο:	32279741
Περίληψη:	The Metal Organic Framework (MOF) of formula {[Ag6(μ3-HMNA)4(μ3-MNA)2]2-·[(Et3NH)+]2·(DMSO)2·(H2O)} (AGMNA), a known efficient antimicrobial compound which contains the anti-metabolite, 2-thio-nicotinic acid (H2MNA), was incorporated in polymer hydrogels using, hydroxyethyl-methacrylate (HEMA). The material pHEMA@AGMNA-1 was characterized by X-ray fluorescence (XRF) spectroscopy, X-ray powder diffraction analysis (XRPD), Scanning Electron Microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), Thermogravimetric Differential Thermal Analysis (TG-DTA), Differential Scanning Calorimetry (DTG/DSC), attenuated total reflection spectroscopy (FT-IR-ATR) and Ultrasonic Imaging. The antimicrobial capacity of pHEMA@AGMNA-1 was evaluated against the Gram negative bacterial strain Pseudomonas aeruginosa and the Gram positive ones of the genus of Staphylococcus epidermidis and Staphylococcus aureus, which are the etiology of the microbial keratitis. The % bacterial viability of P. aeruginosa, S. epidermidis and S. aureus upon their incubation with pHEMA@AGMNA-1 discs is significantly low (0.4 ± 0.1%, 1.5 ± 0.4% and 7.7 ± 0.5% respectively). The inhibition zones (IZ) caused by pHEMA@AGMNA-1 discs against P. aeruginosa, S. epidermidis and S. aureus are 14.0 ± 1.1, 11.3 ± 1.3 and 11.8 ± 1.8 mm respectively. Furthermore, pHEMA@AGMNA-1 exhibits low toxicity. Thus, pHEMA@AGMNA-1 might be an efficient candidate for the development of antimicrobial active contact lenses.
Τίτλος πηγής δημοσίευσης:	Materials science & engineering. C, Materials for biological applications
Τόμος/Κεφάλαιο:	111
Σελίδες:	110770
Θεματική Κατηγορία:	[EL] Χημική Βιολογία[EN] Chemical Biology [EL] Οφθαλμολογία[EN] Opthalmology [EL] Χημική τεχνολογία[EN] Chemical technolgy [EL] Ιατρική[EN] Medicine
Λέξεις-Κλειδιά:	Antibacterial active contact lens Antimicrobial materials Hydrogels Microbial keratitis Animals Anti-Bacterial Agents Artemia Calorimetry, Differential Scanning Cell Survival Contact Lenses, Hydrophilic Epithelial Cells Gram-Negative Bacteria Gram-Positive Bacteria Humans Hydrogels Larva Metal-Organic Frameworks Polyhydroxyethyl Methacrylate Spectroscopy, Fourier Transform Infrared
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Elsevier B.V. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S0928493119325949?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/materials-science-and-engineering-c
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο