Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	The conundrum of human immune system "senescence"
Δημιουργός/Συγγραφέας:	Pawelec, Graham Bronikowski, Anne Cunnane, Stephen C Ferrucci, Luigi Franceschi, Claudio Fülöp, Tamas Gaudreau, Pierrette Gladyshev, Vadim N [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Gorbunova, Vera Kennedy, Brian K Larbi, Anis Lemaître, Jean-François Liu, Guang-Hui Maier, Andrea B Morais, José A Nóbrega, Otávio T Moskalev, Alexey Rikkert, Marcel Olde Seluanov, Andrei Senior, Alistair M Ukraintseva, Svetlana Vanhaelen, Quentin Witkowski, Jacek Cohen, Alan A
Ημερομηνία:	2020-12
Γλώσσα:	Αγγλικά
ISSN:	00476374
DOI:	10.1016/j.mad.2020.111357
Άλλο:	32949594
Περίληψη:	There is a great deal of debate on the question of whether or not we know what ageing is (Ref. Cohen et al., 2020). Here, we consider what we believe to be the especially confused and confusing case of the ageing of the human immune system, commonly referred to as "immunosenescence". But what exactly is meant by this term? It has been used loosely in the literature, resulting in a certain degree of confusion as to its definition and implications. Here, we argue that only those differences in immune parameters between younger and older adults that are associated in some definitive manner with detrimental health outcomes and/or impaired survival prospects should be classed as indicators of immunosenescence in the strictest sense of the word, and that in humans we know remarkably little about their identity. Such biomarkers of immunosenescence may nonetheless indicate beneficial effects in other contexts, consistent with the notion of antagonistic pleiotropy. Identifying what could be true immunosenescence in this respect requires examining: (1) what appears to correlate with age, though generality across human populations is not yet confirmed; (2) what clearly is part of a suite of canonical changes in the immune system that happen with age; (3) which subset of those changes accelerates rather than slows aging; and (4) all changes, potentially population-specific, that accelerate agig. This remains an immense challenge. These questions acquire an added urgency in the current SARS-CoV-2 pandemic, given the clearly greater susceptibility of older adults to COVID-19.
Τίτλος πηγής δημοσίευσης:	Mechanisms of ageing and development
Τόμος/Κεφάλαιο:	192
Σελίδες:	111357
Θεματική Κατηγορία:	[EL] Ιατρική-Δημόσια υγεία[EN] Medicine - public aspects [EL] Βιοχημεία[EN] Biochemistry [EL] Ανοσολογία[EN] Immunology
Λέξεις-Κλειδιά:	Cytomegalovirus Human immunosenescence Inflammageing Longitudinal study Vaccination Adult Aged Biomarkers Humans Middle Aged SARS-CoV-2 COVID-19 Immunosenescence Pandemics
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Elsevier B.V. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S0047637420301536?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/mechanisms-of-ageing-and-development
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο