Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Microstructure and biopharmaceutical performances of curcumin-loaded low-energy nanoemulsions containing eucalyptol and pinene: Terpenes' role overcome penetration enhancement effect?
Δημιουργός/Συγγραφέας:	Nikolic, Ines Mitsou, Evgenia Pantelic, Ivana Randjelovic, Danijela Markovic, Bojan [EL] Παπαδημητρίου, Βασιλική[EN] Papadimitriou, Vassiliki [EL] Ξενάκης, Αριστοτέλης[EN] Xenakis, Aristotelis Lunter, Dominique Jasmin Zugic, Ana Savic, Snezana
Ημερομηνία:	2020-01-15
Γλώσσα:	Αγγλικά
ISSN:	09280987
DOI:	10.1016/j.ejps.2019.105135
Άλλο:	31682974
Περίληψη:	The objective of this work was to develop low-energy nanoemulsions for enhanced dermal delivery of curcumin, using monoterpene compounds eucalyptol (EUC) and pinene (PIN) as chemical penetration enhancers. Spontaneous emulsification was the preparation method. All formulations contained 10% of the oil phase (medium-chain triglycerides (MCT), or their mixture with EUC or PIN). Formulations were stabilized by the combination of polysorbate 80 and soybean lecithin (surfactant-to-oil-ratio=1). Concentration of curcumin was set to 3 mg/ml. Average droplet diameter of all tested formulations ranged from 102 nm to 132 nm, but the ones containing monoterpenes had significantly smaller size compared to the MCT formulation. Such finding was profoundly studied through electron paramagnetic resonance spectroscopy, which proved that the presence of monoterpenes modified the nanoemulsions' interfacial environment, resulting in droplet size reduction. The release study of curcumin (using Franz cells) demonstrated that the cumulative amount released after 6 h of the experiment was 10.1 ± 0.2% for the MCT nanoemulsions, 13.9 ± 0.1% and 14.0 ± 0.2% for PIN and EUC formulations, respectively. In vivo tape stripping revealed their performances in delivering curcumin into the skin, indicating the following order: EUC>MCT>PIN. The formulation with EUC was clearly the most successful, giving the highest cumulative amount of curcumin that penetrated per surface unit: 34.24±5.68 µg/cm2. The MCT formulation followed (30.62±2.61 µg/cm2) and, finally, the one with PIN (21.61±0.11 µg/cm2). These results corelated with curcumin's solubility in the chosen oils: 4.18±0.02 mg/ml for EUC, 1.67±0.04 mg/ml for MCT and 0.21±0.01 mg/ml for PIN. Probably, higher solubility in the oil phase of the nanoemulsion promoted curcumin's solubility in the superficial skin layers, providing enhanced penetration.
Τίτλος πηγής δημοσίευσης:	European Journal of Pharmaceutical Sciences
Τόμος/Κεφάλαιο:	142
Σελίδες:	105135
Θεματική Κατηγορία:	[EL] Χημική Βιολογία[EN] Chemical Biology [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	Curcumin Electron paramagnetic resonance spectroscopy Interfacial dynamics Low-energy nanoemulsion Monoterpene Penetration Administration, Cutaneous Adult Emulsions Eucalyptol Female Humans Lecithins Monoterpenes Nanoparticles Nanostructures Oils Polysorbates Skin Skin Absorption Solubility Surface-Active Agents Terpenes Young Adult
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Elsevier B.V. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/abs/pii/S0928098719304087?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/european-journal-of-pharmaceutical-sciences
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο