Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Curcumin-loaded low-energy nanoemulsions: Linking EPR spectroscopy-analysed microstructure and antioxidant potential with in vitro evaluated biological activity
Δημιουργός/Συγγραφέας:	Nikolic, Ines Mitsou, Evgenia Damjanovic, Ana [EL] Παπαδημητρίου, Βασιλική[EN] Papadimitriou, Vassiliki Antic-Stankovic, Jelena Stanojevic, Boban [EL] Ξενάκης, Αριστοτέλης[EN] Xenakis, Aristotelis Savic, Snezana
Ημερομηνία:	2020
Γλώσσα:	Αγγλικά
ISSN:	01677322
DOI:	10.1016/j.molliq.2020.112479
Περίληψη:	The objective of this work was to investigate and profoundly characterize low-energy nanoemulsions as multifunctional carriers, with slight reference to dermal administration. An evidence-based approach was offered for deepening the knowledge on their formation via spontaneous emulsification. Curcumin, a compound of natural origin, potentially powerful therapeutic, was chosen as a model API. Due to curcumin's demanding properties (instability, poor solubility, low permeability), its potentials remain unreached. Low-energy nanoemulsions were considered carriers capable of overcoming imposed obstacles. Formulation consisting of Polysorbate 80 and soybean lecithin as stabilizers (9:1, 10%), medium-chain triglycerides as the oil phase (10%) and ultrapure water was selected for curcumin incorporation in 3 different concentrations (1, 2 and 3 mg/mL). Physicochemical stability was demonstrated during 3 months of monitoring (mean droplet size: 111.3-146.8 nm; PDI < 0.2; pH: 4.73-5.73). Curcumin's release from developed vehicles followed Higuchi's kinetics. DPPH (IC50 = 0.1187 mg/ mL) and FRAP (1.19 +/- 0.02 mmol/g) assays confirmed that curcumin acts as a potent antioxidant through different mechanisms, with no alterations after incorporation in the formulation. High biocompatibility in line with antigenotoxic activity of curcumin-loaded formulations (protective and reparative) was estimated through Comet assay. A multidisciplinary approach is needed to fully characterize developed systems, directing them to more concrete application possibilities.
Τίτλος πηγής δημοσίευσης:	Journal of Molecular Liquids
Τόμος/Κεφάλαιο:	301
Σελίδες:	112479
Θεματική Κατηγορία:	[EL] Χημική Βιολογία[EN] Chemical Biology [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	Low - energy nanoemulsions Spontaneous emulsification Curcumin Atomic force microscopy Antioxidant activity (Anti)genetoxicity
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Elsevier B.V. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/abs/pii/S0167732219363895?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/journal-of-molecular-liquids
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο