Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Poly[oligo(ethylene glycol) methacrylate]-b-poly[(vinyl benzyl trimethylammonium chloride)] Based multifunctional hybrid nanostructures encapsulating magnetic nanoparticles and DNA
Δημιουργός/Συγγραφέας:	Chroni, Angeliki Forys, Aleksander Trzebicka, Barbara Alemayehu, Adam Tyrpekl, Vaclav [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	MDPI
Ημερομηνία:	2020-06-03
Γλώσσα:	Αγγλικά
ISSN:	2073-4360
DOI:	10.3390/polym12061283
Άλλο:	32503350
Περίληψη:	We report on the preparation of novel and multifunctional hybrid spherical-shaped nanostructures involving a double-hydrophilic block copolymer, namely the neutral cationic poly[oligo(ethylene glycol) methacrylate]-b-poly[(vinyl benzyl trimethylammonium chloride)] (POEGMA-b-PVBTMAC) diblock copolymer, initially complexed with hydrophilic anionic magnetic nanoparticles (MNPs), and subsequently, with short deoxyribonucleic acid (113 bases DNA). The POEGMA-b-PVBTMAC copolymer, the copolymer/MNPs and the copolymer/MNPs/DNA tricomponent hybrid electrostatic complexes were studied by dynamic/electrophoretic light scattering (DLS/ELS) and cryogenic transmission electron microscopy (cryo-TEM) techniques for the determination of their structure and solution properties. The MNPs were complexed efficiently with the oppositely charged diblock chains, leading to well-defined hybrid organic-inorganic spherical-shaped nanostructures. A significant aggregation tendency of the MNPs is noticed in cryo-TEM measurements after the electrostatic complexation of DNA, implying an accumulation of the DNA macromolecules on the surface of the hybrid tricomponent complexes. Magnetophoretic experiments verified that the MNPs maintain their magnetic properties after the complexation initially with the copolymer, and subsequently, within the block polyelectrolyte/MNPs/DNA nanostructures.
Τίτλος πηγής δημοσίευσης:	Polymers Special Issue: Polymer Hybrid Nanomaterials
Τόμος/Κεφάλαιο:	12
Τεύχος:	6
Σελίδες:	1283
Θεματική Κατηγορία:	[EL] Χημεία (Γενικά)[EN] Chemistry (General) [EL] Χημική τεχνολογία[EN] Chemical technolgy
Λέξεις-Κλειδιά:	Cationic polyelectrolytes Double Hydrophilic Block Copolymer Gene delivery Hybrid nanoparticles Magnetic nanoparticles Theranostics
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2073-4360/12/6/1283
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/journal/polymers
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο