Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Biocompatible PEO-b-PCL nanosized micelles as drug carriers: Structure and drug-polymer interactions
Δημιουργός/Συγγραφέας:	Chroni, Angeliki Mavromoustakos, Thomas [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	MDPI
Ημερομηνία:	2020-09-18
Γλώσσα:	Αγγλικά
ISSN:	2079-4991
DOI:	10.3390/nano10091872
Άλλο:	32962043
Περίληψη:	We report on the preparation of drug nanocarriers by encapsulating losartan potassium (LSR) into amphiphilic block copolymer micelles, utilizing the biocompatible/biodegradable poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) diblock copolymer. The PEO-b-PCL micelles and LSR-loaded PEO-b-PCL nanocarriers were prepared by organic solvent evaporation method (OSEM). Light scattering and nuclear magnetic resonance (NMR) provide information on micelle structure and polymer-drug interactions. According to dynamic light scattering (DLS) analysis, the PEO-b-PCL micelles and LSR-loaded PEO-b-PCL nanocarriers formed nanostructures in the range of 17-26 nm in aqueous milieu. Attenuated total reflection Fourier transform infrared (ATR-FTIR) and ultraviolet-visible (UV-Vis) measurements confirmed the presence of LSR in the polymeric drug solutions. NMR results proved the successful encapsulation of LSR into the PEO-b-PCL micelles by analyzing the drug-micelles intermolecular interactions. Specifically, 2D-NOESY experiments clearly evidenced the intermolecular interactions between the biphenyl ring and butyl chain of LSR structure with the methylene signals of PCL. Additionally, NMR studies as a function of temperature demonstrated an unexpected, enhanced proton mobility of the PEO-b-PCL micellar core in D2O solutions, probably caused by the melting of the PCL hydrophobic core.
Τίτλος πηγής δημοσίευσης:	Nanomaterials (Basel, Switzerland) Special Issue: Nanodispersions Based on Biocompatibility
Τόμος/Κεφάλαιο:	10
Τεύχος:	9
Σελίδες:	1872
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Φασματοσκοπία[EN] Spectroscopy [EL] Χημική τεχνολογία[EN] Chemical technolgy [EL] Φασματοσκοπία[EN] Spectroscopy
Λέξεις-Κλειδιά:	Amphiphilic block copolymers Drug delivery systems Drug encapsulation Drug-polymer intermolecular interactions Organic solvent evaporation method Polymeric nanocarriers
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2079-4991/10/9/1872
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/journal/nanomaterials
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο