Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	DNA Damage response and oxidative stress in systemic autoimmunity: Review
Δημιουργός/Συγγραφέας:	[EL] Σουλιώτης, Βασίλης Λ.[EN] Souliotis, Vassilis L. Vlachogiannis, Nikolaos I Pappa, Maria Argyriou, Alexandra Ntouros, Panagiotis A Sfikakis, Petros P
Εκδότης:	MDPI
Ημερομηνία:	2019-12-20
Γλώσσα:	Αγγλικά
ISSN:	1422-0067
DOI:	10.3390/ijms21010055
Άλλο:	31861764
Περίληψη:	The DNA damage response and repair (DDR/R) network, a sum of hierarchically structured signaling pathways that recognize and repair DNA damage, and the immune response to endogenous and/or exogenous threats, act synergistically to enhance cellular defense. On the other hand, a deregulated interplay between these systems underlines inflammatory diseases including malignancies and chronic systemic autoimmune diseases, such as systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis. Patients with these diseases are characterized by aberrant immune response to self-antigens with widespread production of autoantibodies and multiple-tissue injury, as well as by the presence of increased oxidative stress. Recent data demonstrate accumulation of endogenous DNA damage in peripheral blood mononuclear cells from these patients, which is related to (a) augmented DNA damage formation, at least partly due to the induction of oxidative stress, and (b) epigenetically regulated functional abnormalities of fundamental DNA repair mechanisms. Because endogenous DNA damage accumulation has serious consequences for cellular health, including genomic instability and enhancement of an aberrant immune response, these results can be exploited for understanding pathogenesis and progression of systemic autoimmune diseases, as well as for the development of new treatments.
Τίτλος πηγής δημοσίευσης:	International journal of molecular sciences Special Issue: DNA Damage, Oxidative Stress and Related Metabolic By-Products in Cancer and Environmental Studies
Τόμος/Κεφάλαιο:	21
Τεύχος:	1
Σελίδες:	55
Θεματική Κατηγορία:	[EL] Κυτταρολογία[EN] Cytology [EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Βιοχημεία[EN] Biochemistry [EL] Ανοσολογία[EN] Immunology
Λέξεις-Κλειδιά:	DNA damage response and repair network Abasic sites Apoptosis Autoimmunity Chromatin organization Immune response Oxidative stress Rheumatoid arthritis Systemic lupus erythematosus Systemic sclerosis Animals Arthritis, Rheumatoid Autoimmune Diseases DNA Damage Humans Lupus Erythematosus, Systemic Scleroderma, Systemic Autoimmunity DNA Repair Oxidative Stress
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/1422-0067/21/1/55
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/journal/ijms
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο