Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	RAS and BRAF in the foreground for non-small cell lung cancer and colorectal cancer: Similarities and main differences for prognosis and therapies: Review
Δημιουργός/Συγγραφέας:	Giopanou, Ioanna [EL] Πίντζας, Αλέξανδρος[EN] Pintzas, Alexander
Εκδότης:	Elsevier
Ημερομηνία:	2020-02
Γλώσσα:	Αγγλικά
DOI:	10.1016/j.critrevonc.2019.102859
Άλλο:	31927392
Περίληψη:	Lung and colorectal cancer are included in the most tremendously threatening diseases in terms of incidence and death. Although they are located in completely different organs and differ in various characteristics they do share some common features, especially regarding their molecular mutational profile. Among several commonly mutated genes KRAS and BRAF are spotted to be highly associated with patient's poor disease outcome and resistance to targeted therapies mostly in liaison with other mutant activated genes. Many studies have shed light in these mechanisms for disease progression and numerous preclinical models, clinical trials and meta-analysis reports investigate the impact of specific treatments or combination of therapies. The present review is an effort to compare the mutational imprint of these genes between the two diseases and their impact in prognosis, current therapy, mechanisms of therapy resistance and future therapeutic plans and provide a spherical perspective regarding the systemic molecular profile of cancer.
Τίτλος πηγής δημοσίευσης:	Critical reviews in oncology/hematology
Τόμος/Κεφάλαιο:	146
Σελίδες:	102859
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Γενετική[EN] Genetics [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Ιατρική[EN] Medicine
Λέξεις-Κλειδιά:	BRAF Colorectal cancer Inhibitors Lung cancer RAS Therapy Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Carcinoma, Non-Small-Cell Lung Colorectal Neoplasms Disease Progression Humans Lung Neoplasms Mutation Predictive Value of Tests Prognosis Proto-Oncogene Proteins B-raf Treatment Outcome ras Proteins
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2019 Elsevier B.V. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/abs/pii/S1040842819302458?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/critical-reviews-in-oncology-hematology
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο