Εξειδίκευση τύπου :	Κεφάλαιο βιβλίου
Τίτλος:	Dynamics and physics of integrin activation in tumor cells by nano-sized extracellular ligands and electromagnetic fields
Δημιουργός/Συγγραφέας:	[EL] Κεφαλάς, Αλκιβιάδης Κωνσταντίνος[EN] Cefalas, Alciviadis Constantinos Gavriil, Vassilios Ferraro, Angelo [EL] Κόλλια, Ζωή[EN] Kollia, Zoe [EL] Σαραντοπούλου, Ευαγγελία[EN] Sarantopoulou, Evangelia
Επιμελητής έκδοσης:	Vicente-Manzanares, Miguel
Εκδότης:	Humana
Τόπος έκδοσης:	New York
Ημερομηνία:	2021
Γλώσσα:	Αγγλικά
ISBN:	978-1-0716-0961-3 978-1-0716-0962-0
ISSN:	1064-3745 1940-6029
DOI:	10.1007/978-1-0716-0962-0_12
Περίληψη:	Integrins are stress-sensing proteins expressed on the surface of cells. They regulate bidirectional signal transduction during cell-cell or cell–extracellular matrix (ECM) contacts. Integrins link the ECM with the cytoplasm through interaction with their ligands. Biophysically, such interactions can be understood as changes in stress fields at specific integrin stress-sensing domains, such as the MIDAS and ADMIDAS domains. Stress changes between ligands and cytoskeletal structures are involved in cancer cell growth by altering signal transduction pathways dependent on integrin activation. In this chapter, previous results regarding integrin activation and tumor cell growth using nanoparticles (NPs) of different materials, sizes and shapes are placed within a framework of polarized NPs in the ECM by external electromagnetic fields, in which the synergic action between polarized NPs and electromagnetic fields activates the integrins. Small size NPs activate integrins via the polar component of the dipole force between NPs and integrin sensing stress sites, while large size NPs exercise a similar action via the radial component. A quantum electrodynamic model also accounts for ECM overstressing by electromagnetic mode trapping between coherent symmetric and antisymmetric quantum states.
Τίτλος πηγής δημοσίευσης:	The Integrin Interactome: Methods and Protocols
Σελίδες:	197–233
Σειρά δημοσίευσης:	Methods in Molecular Biology
Αρ. σειράς:	2217
Θεματική Κατηγορία:	[EL] Κυτταρολογία[EN] Cytology [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Βιοτεχνολογία[EN] Biotechnology [EL] Φυσική[EN] Physics [EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Integrins MIDAS ADMIDAS Electromagnetic fields Quantum biology Nanoparticles mechanosensor Coherent state Quantum electrodynamics
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 Springer Science+Business Media, LLC, part of Springer Nature
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://link.springer.com/protocol/10.1007/978-1-0716-0962-0_12
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://link.springer.com/book/10.1007/978-1-0716-0962-0
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο