Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Poly(2‐(dimethylamino)ethyl methacrylate)‐b‐poly(hydroxypropyl methacrylate) copolymers/bovine serum albumin complexes in aqueous solutions
Δημιουργός/Συγγραφέας:	Sentoukas, Theodore [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	John Wiley and Sons
Ημερομηνία:	2020
Γλώσσα:	Αγγλικά
ISSN:	2642-4150 2642-4169
DOI:	10.1002/pol.20200065
Περίληψη:	Complexation ability of poly(2-(dimethylamino)ethyl methacrylate)-b-poly(hydroxy propyl methacrylate) (PDMAEMA-b-PHPMA) amphiphilic doubly thermo-responsive block copolymers, and their quaternized counterparts QPDMAEMA-b-PHPMA, toward bovine serum albumin (BSA) is studied in aqueous solutions. The PDMAEMA-b-PHPMA amphiphilic block copolymers self-assemble in nanostructured aggregates with PDMAEMA coronas having different inner structure and micro-polarity depending on the solubilization protocol utilized when inserted in aqueous media. By incorporating different BSA concentrations, we investigate the copolymer–protein interactions by light scattering measurements in aqueous solutions in a broad temperature range, utilizing different solubilization protocols for the copolymers. Fluorescence spectroscopy and ζ-potential measurements were also utilized to investigate the structure and properties of the copolymer/protein complexes formed in each case. Such knowledge may lead to a better understanding of the inner structure and micro polarity of the nanostructured aggregates formed by the novel (Q)PDMAEMA-b-PHPMA copolymers, along with their potential abilities in nanocarrier formation, protein complexation, stabilization, and delivery.
Τίτλος πηγής δημοσίευσης:	Journal of Polymer Science
Τόμος/Κεφάλαιο:	58
Τεύχος:	9
Σελίδες:	1241-1252
Θεματική Κατηγορία:	[EL] Χημική Βιολογία[EN] Chemical Biology [EL] Φυσική[EN] Physics [EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Φασματοσκοπία[EN] Spectroscopy
Λέξεις-Κλειδιά:	Block copolymer Light scattering pH responsive RAFT Thermoresponsive Protein complexation BSA
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Wiley Periodicals, Inc.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://onlinelibrary.wiley.com/doi/10.1002/pol.20200065
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://onlinelibrary.wiley.com/journal/26424169
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο