Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Long non-coding RNAs (lncRNAs) in response and resistance to cancer immunosurveillance and immunotherapy
Δημιουργός/Συγγραφέας:	Eptaminitaki, Giasemi C Wolff, Nora [EL] Στέλλας, Δημήτρης[EN] Stellas, Dimitris Sifakis, Konstantinos Baritaki, Stavroula
Εκδότης:	MDPI
Ημερομηνία:	2021-11-26
Γλώσσα:	Αγγλικά
ISSN:	2073-4409
DOI:	10.3390/cells10123313
Άλλο:	34943820
Περίληψη:	Long non-coding RNAs (lncRNAs) are critical regulatory elements in cellular functions in states of both normalcy and disease, including cancer. LncRNAs can influence not only tumorigenesis but also cancer features such as metastasis, angiogenesis and resistance to chemo-and immune-mediated apoptotic signals. Several lncRNAs have been demonstrated to control directly or indirectly the number, type and activities of distinct immune cell populations of adaptive and innate immunities within and without the tumor microenvironment. The disruption of lncRNA expression in both cancer and immune cells may reflect alterations in tumor responses to cancer immunosurveillance and immunotherapy, thus providing new insights into lncRNA biomarker-based prognostic and therapeutic cancer assessment. Here we present an overview on lncRNAs' functions and underlying molecular mechanisms related to cancer immunity and conventional immunotherapy, with the expectation that any elucidations may lead to a better understanding and management of cancer immune escape and response to current and future immunotherapeutics.
Τίτλος πηγής δημοσίευσης:	Cells Special Issue: Role of Non-coding RNA in Health and Disease
Τόμος/Κεφάλαιο:	10
Τεύχος:	12
Σελίδες:	3313
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Κυτταρολογία[EN] Cytology [EL] Ανοσολογία[EN] Immunology [EL] Βιοχημεία[EN] Biochemistry [EL] Ιατρική (Γενικά)[EN] Medicine (General)
Λέξεις-Κλειδιά:	Immunosurveillance Immunotherapy Long non-coding RNAs Tumor resistance Animals Drug Resistance, Neoplasm Humans Immune Evasion Neoplastic Stem Cells RNA, Long Noncoding Monitoring, Immunologic
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2073-4409/10/12/3313
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/journal/cells
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο