Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Low-Grade systemic inflammation interferes with anabolic and catabolic characteristics of the aged human skeletal muscle
Δημιουργός/Συγγραφέας:	Draganidis, Dimitrios Jamurtas, Athanasios Z [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Mastorakos, George Jung, Tobias Grune, Tilman Papadopoulos, Constantinos Papanikolaou, Konstantinos Papassotiriou, Ioannis Papaevgeniou, Nikoletta Poulios, Athanasios Batrakoulis, Alexios Deli, Chariklia K Georgakouli, Kalliopi Chatzinikolaou, Athanasios Karagounis, Leonidas G Fatouros, Ioannis G
Εκδότης:	Hindawi
Ημερομηνία:	2021
Γλώσσα:	Αγγλικά
DOI:	10.1155/2021/8376915
Άλλο:	34917235
Περίληψη:	Aging is associated with the development of chronic low-grade systemic inflammation (LGSI) characterized by increased circulating levels of proinflammatory cytokines and acute phase proteins such as C-reactive protein (CRP). Collective evidence suggests that elevated levels of inflammatory mediators such as CRP, interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α) are correlated with deteriorated skeletal muscle mass and function, though the molecular footprint of this observation in the aged human skeletal muscle remains obscure. Based on animal models showing impaired protein synthesis and enhanced degradation in response to LGSI, we compared here the response of proteolysis- and protein synthesis-related signaling proteins as well as the satellite cell and amino acid transporter protein content between healthy older adults with increased versus physiological blood hs-CRP levels in the fasted (basal) state and after an anabolic stimulus comprised of acute resistance exercise (RE) and protein feeding. Our main findings indicate that older adults with increased hs-CRP levels demonstrate (i) increased proteasome activity, accompanied by increased protein carbonylation and IKKα/β phosphorylation; (ii) reduced Pax7+ satellite cells; (iii) increased insulin resistance, at the basal state; and (iv) impaired S6 ribosomal protein phosphorylation accompanied by hyperinsulinemia following an acute RE bout combined with protein ingestion. Collectively, these data provide support to the concept that age-related chronic LGSI may upregulate proteasome activity via induction of the NF-κB signaling and protein oxidation and impair the insulin-dependent anabolic potential of human skeletal muscle.
Τίτλος πηγής δημοσίευσης:	Oxidative medicine and cellular longevity Special issue: Redox Perturbations in Exercise and Inflammation
Τόμος/Κεφάλαιο:	2021
Σελίδες:	8376915
Θεματική Κατηγορία:	[EL] Ιατρική[EN] Medicine [EL] Βιοχημεία[EN] Biochemistry [EL] Κυτταρολογία[EN] Cytology
Λέξεις-Κλειδιά:	Aged Healthy Volunteers Humans Hyperinsulinism Inflammation Inflammation Mediators Male Muscle, Skeletal Phosphorylation Ribosomal Protein S6 Kinases Exercise Insulin Resistance Proteolysis
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 by the Authors
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.hindawi.com/journals/omcl/2021/8376915/
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.hindawi.com/journals/omcl/
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο