Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Linking the IL-17A immune response with NMR-based faecal metabolic profile in IBD patients treated with Mastiha
Δημιουργός/Συγγραφέας:	Amerikanou, Charalampia Dimitropoulou, Eirini Gioxari, Aristea Papada, Efstathia Tanaini, Anthi Fotakis, Charalambos [EL] Ζουμπουλάκης, Παναγιώτης[EN] Zoumpoulakis, Panagiotis Kaliora, Andriana C
Εκδότης:	Elsevier
Ημερομηνία:	2021-06
Γλώσσα:	Αγγλικά
ISSN:	07533322
DOI:	10.1016/j.biopha.2021.111535
Άλλο:	34311533
Περίληψη:	Dysregulation of intestinal immune response plays a critical role in the pathogenesis of Inflammatory Bowel Disease (IBD). Mastiha's anti-inflammatory properties are well established. Our aim was to investigate Mastiha's regulatory effect on IL-17A serum levels in IBD patients. Alterations of the faecal metabolome as a functional readout of microbial activity were explored. A randomized, double-blind, placebo-controlled, parallel-group design was applied for a total of 3 months in active and 6 months in inactive IBD patients. Serum IL-17A increased significantly in Mastiha group (p = 0.006), and the mean change differed significantly between Mastiha and placebo (p = 0.003) even after adjusting for age, sex and BMI (p = 0.001) in inactive patients. In inactive UC patients IL-17A decreased significantly only in placebo (p = 0.033). No significant differences were detected in active disease. Faecal metabolomics indicated that intervention with Mastiha influenced considerably the metabolic profile of IBD patients in remission exhibiting, in between others, increased levels of glycine and tryptophan. Glycine has been proposed to have a therapeutic effect against IBD, while tryptophan derivatives are involved in immunoregalutory mechanisms, such as the Th17 cells differentiation. Thus, it is quite possible that the immunoregulatory role of Mastiha in quiescent IBD involves the regulation of Th17 cells function and differentiation.
Τίτλος πηγής δημοσίευσης:	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Τόμος/Κεφάλαιο:	138
Σελίδες:	111535
Θεματική Κατηγορία:	[EL] Ιατρική (Γενικά)[EN] Medicine (General) [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Κυτταρολογία[EN] Cytology [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Faecal metabolomics Inflammatory bowel diseases Interleukin-17A Mastiha Adolescent Adult Aged Anti-Inflammatory Agents Colitis, Ulcerative Crohn Disease Double-Blind Method Feces Female Humans Interleukin-17 Male Mastic Resin Middle Aged Th17 Cells Time Factors Treatment Outcome Young Adult Metabolome Metabolomics Proton Magnetic Resonance Spectroscopy
Τοπική Κάλυψη:	Greece
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 The Authors. Published by Elsevier Masson SAS.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S0753332221003206?via%3Dihub
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/biomedicine-and-pharmacotherapy
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο