Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Age, sex, and BMI influence on copper, zinc, and their major serum carrier proteins in a large european population including nonagenarian offspring from MARK-AGE study
Δημιουργός/Συγγραφέας:	Piacenza, Francesco Giacconi, Robertina Costarelli, Laura Basso, Andrea Bürkle, Alexander Moreno-Villanueva, María Dollé, Martijn E T Jansen, Eugène Grune, Tilman Weber, Daniela Stuetz, Wolfgang [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Schön, Christiane Bernhardt, Jürgen Grubeck-Loebenstein, Beatrix Sikora, Ewa Toussaint, Olivier Debacq-Chainiaux, Florence Franceschi, Claudio Capri, Miriam Hervonen, Antti Hurme, Mikko Slagboom, Eline Breusing, Nicolle Mocchegiani, Eugenio Malavolta, Marco
Εκδότης:	Oxford University Press
Ημερομηνία:	2021-11-15
Γλώσσα:	Αγγλικά
ISSN:	1079-5006 1758-535X
DOI:	10.1093/gerona/glab134
Άλλο:	33983441
Περίληψη:	The analysis of copper (Cu) and zinc (Zn) along with their major serum carriers, albumin (Alb) and ceruloplasmin (Cp), could provide information on the capacity of humans to maintain homeostasis of metals (metallostasis). However, their relationship with aging, sex, body mass index, as well as with nutritional and inflammatory markers was never investigated in a large-scale study. Here, we report results from the European large-scale cross-sectional study MARK-AGE in which Cu, Zn, Alb, Cp, as well as nutritional and inflammatory parameters were determined in 2424 age-stratified participants (35-75 years), including the general population (RASIG), nonagenarian offspring (GO), a well-studied genetic model of longevity, and spouses of GO (SGO). In RASIG, Cu to Zn ratio and Cp to Alb ratio were higher in women than in men. Both ratios increased with aging because Cu and Cp increased and Alb and Zn decreased. Cu, Zn, Alb, and Cp were found associated with several inflammatory as well as nutritional biomarkers. GO showed higher Zn levels and higher Zn to Alb ratio compared to RASIG, but we did not observe significant differences with SGO, likely as a consequence of the low sample size of SGO and the shared environment. Our results show that aging, sex, body mass index, and GO status are characterized by different levels of Cu, Zn, and their serum carrier proteins. These data and their relationship with inflammatory biomarkers support the concept that loss of metallostasis is a characteristic of inflammaging.
Τίτλος πηγής δημοσίευσης:	The journals of gerontology. Series A, Biological sciences and medical sciences
Τόμος/Κεφάλαιο:	76
Τεύχος:	12
Σελίδες:	2097–2106
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Ιατρική[EN] Medicine
Λέξεις-Κλειδιά:	Albumin Ceruloplasmin Chronic inflammatory status Homeostasis Metallostasis Aged Biomarkers Body Mass Index Carrier Proteins Cross-Sectional Studies Female Humans Male Nonagenarians Age Factors Copper Sex Factors Zinc
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 Oxford University Press
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://academic.oup.com/biomedgerontology/article/76/12/2097/6275243
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://academic.oup.com/biomedgerontology
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο